TY - JOUR
T1 - Incidence of neonatal hypertension from a large multicenter study [Assessment of Worldwide Acute Kidney Injury Epidemiology in Neonates—AWAKEN]
AU - On behalf of the Neonatal Kidney Collaborative (NKC)
AU - Kraut, Emily J.
AU - Boohaker, Louis J.
AU - Askenazi, David J.
AU - Fletcher, Jeffery
AU - Kent, Alison L.
AU - Selewski, David T.
AU - Sarkar, Subrata
AU - Kent, Alison
AU - Fletcher, Jeffery
AU - Abitbol, Carolyn L.
AU - DeFreitas, Marissa
AU - Duara, Shahnaz
AU - Charlton, Jennifer R.
AU - Guillet, Ronnie
AU - D’Angio, Carl
AU - Mian, Ayesa
AU - Rademacher, Erin
AU - Mhanna, Maroun J.
AU - Raina, Rupesh
AU - Kumar, Deepak
AU - Ambalavanan, Namasivayam
AU - Arikan, Ayse Akcan
AU - Rhee, Christopher J.
AU - Goldstein, Stuart L.
AU - Nathan, Amy T.
AU - Bhutada, Alok
AU - Rastogi, Shantanu
AU - Bonachea, Elizabeth
AU - Ingraham, Susan
AU - Mahan, John
AU - Nada, Arwa
AU - Brophy, Patrick D.
AU - Colaizy, Tarah T.
AU - Klein, Jonathan M.
AU - Cole, F. Sessions
AU - Davis, T. Keefe
AU - Dower, Joshua
AU - Milner, Lawrence
AU - Smith, Alexandra
AU - Fuloria, Mamta
AU - Reidy, Kimberly
AU - Kaskel, Frederick J.
AU - Gien, Jason
AU - Gist, Katja M.
AU - Hanna, Mina H.
AU - Hingorani, Sangeeta
AU - Starr, Michelle
AU - Joseph, Catherine
AU - DuPont, Tara
AU - Ohls, Robin
N1 - Publisher Copyright:
© 2018, International Pediatric Research Foundation, Inc.
Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 2018/8/1
Y1 - 2018/8/1
N2 - Background: Hypertension occurs in up to 3% of neonates admitted to the Neonatal Intensive Care Unit (NICU), and is a potentially under-recognized condition. The aim of this study was to examine the incidence of documented and undiagnosed hypertension from the 24-center Assessment of Worldwide Acute Kidney Injury Epidemiology in Neonates (AWAKEN) database, and to assess risk factors for hypertension according to gestational age. Methods: Diagnosed hypertension was documented if an infant had a discharge diagnosis of hypertension and/or discharged on antihypertensive medications. Undiagnosed hypertension was defined when infants did not have a diagnosis of hypertension, but >50% of the lowest mean, diastolic and systolic blood pressure recordings were >95th percentile for gestational age. Results: Of the 2162 neonates enrolled in the study, hypertension was documented in 1.8%. An additional 3.7% were defined as having undiagnosed hypertension. There was a significant correlation with neonatal hypertension and acute kidney injury (AKI). Additional risk factors for neonatal hypertension were hyperbilirubinaemia, Caucasian race, outborn, vaginal delivery, and congenital heart disease. Protective factors were small for gestational age, multiple gestations, and steroids for fetal maturation. Conclusions: Neonatal hypertension may be an under-recognized condition. AKI and other risk factors predispose infants to hypertension.
AB - Background: Hypertension occurs in up to 3% of neonates admitted to the Neonatal Intensive Care Unit (NICU), and is a potentially under-recognized condition. The aim of this study was to examine the incidence of documented and undiagnosed hypertension from the 24-center Assessment of Worldwide Acute Kidney Injury Epidemiology in Neonates (AWAKEN) database, and to assess risk factors for hypertension according to gestational age. Methods: Diagnosed hypertension was documented if an infant had a discharge diagnosis of hypertension and/or discharged on antihypertensive medications. Undiagnosed hypertension was defined when infants did not have a diagnosis of hypertension, but >50% of the lowest mean, diastolic and systolic blood pressure recordings were >95th percentile for gestational age. Results: Of the 2162 neonates enrolled in the study, hypertension was documented in 1.8%. An additional 3.7% were defined as having undiagnosed hypertension. There was a significant correlation with neonatal hypertension and acute kidney injury (AKI). Additional risk factors for neonatal hypertension were hyperbilirubinaemia, Caucasian race, outborn, vaginal delivery, and congenital heart disease. Protective factors were small for gestational age, multiple gestations, and steroids for fetal maturation. Conclusions: Neonatal hypertension may be an under-recognized condition. AKI and other risk factors predispose infants to hypertension.
UR - http://www.scopus.com/inward/record.url?scp=85047273981&partnerID=8YFLogxK
U2 - 10.1038/s41390-018-0018-8
DO - 10.1038/s41390-018-0018-8
M3 - Article
C2 - 29795211
AN - SCOPUS:85047273981
VL - 84
SP - 279
EP - 289
JO - Pediatric Research
JF - Pediatric Research
SN - 0031-3998
IS - 2
ER -