Incidence and risk factors for sigmoid venous thrombosis following CPA tumor resection

Matthew Shew, Hannah Kavookjian, Kelly Dahlstrom, Thomas Muelleman, James Lin, Paul Camarata, Luke N. Ledbetter, Hinrich Staecker

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Objective: Our primary aim was to determine the incidence of sigmoid venous thrombosis (SVT) and determine risks factors and sequelae of SVT following cerebellopontine angle tumor resection. Study Design: Retrospective cohort study. Setting: Academic tertiary care hospital. Patients: Patients over 18 years of age who underwent resection of cerebellopontine angle meningioma or vestibular schwannoma from January 2005 to April 2016 who had postoperative magnetic resonance imaging. Intervention(s): Diagnostic. Main Outcome Measure(s): Incidence of postoperative sigmoid venous thrombosis (SVT) from official radiology reports was compared with retrospective imaging review by our institutional neuroradiologists. Data collected included age, length of stay, body mass index, surgical approach, and postoperative complications. Results: A total of 127 patients were identified. Official radiology reads significantly underreported the incidence of postoperative SVT compared with retrospective review by our institutional neuroradiologist for patients who underwent routine postoperative imaging (n = 4 [3.1%] versus n = 22 [17.3%]; p < 0.001). There was a statistical trend toward increased risk for thrombosis in patients undergoing translabyrinthine and staged resection that did not reach significance (p = 0.068). Cerebrospinal fluid (CSF) leak incidence in patients with thrombosis was significantly increased (n = 9 [37.5%] versus n = 13 [12.6%]; p = 0.007). When controlling for approach, the presence of thrombus was associated with a more then three-fold increase in odds of CSF leak (OR = 3.28, 95% CI: 1.12-9.48, p = 0.030). There was no correlation between SVT and age (p = 0.788), body mass index (p = 0.686), length of stay (p = 0.733), preoperative tumor size (p = 0.555), or increased postoperative ICP (p = 0.645). Only one patient was symptomatic from sigmoid thrombosis compared with 21 who were not. Conclusion: Incidence of SVT is significantly underreported and may predispose patients to increase risk for CSF leak. Staged and translabyrinthine approaches demonstrate an increased trend toward thrombosis risk. Our findings suggest it may not be necessary to treat asymptomatic SVT.

Original languageEnglish
Pages (from-to)e376-e380
JournalOtology and Neurotology
Volume39
Issue number5
DOIs
StatePublished - Jun 1 2018

Keywords

  • CPA tumor
  • Meningioma
  • Sigmoid venous thrombosis
  • Vestibular schwannoma

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