Incidence and management of life-threatening adverse events during cardiac catheterization for congenital heart disease

C. Huie Lin, Sanjeet Hegde, Audrey C. Marshall, Diego Porras, Kimberlee Gauvreau, David T. Balzer, Robert H. Beekman, Alejandro Torres, Julie A. Vincent, John W. Moore, Ralf Holzer, Laurie Armsby, Lisa Bergersen

Research output: Contribution to journalArticlepeer-review

44 Scopus citations


Continued advancements in congenital cardiac catheterization and interventions have resulted in increased patient and procedural complexity. Anticipation of life-threatening events and required rescue measures is a critical component to preprocedural preparation. We sought to determine the incidence and nature of life-threatening adverse events in congenital and pediatric cardiac catheterization, risk factors, and resources necessary to anticipate and manage events. Data from 8905 cases performed at the 8 participating institutions of the Congenital Cardiac Catheterization Project on Outcomes were captured between 2007 and 2010 [median 1,095/site (range 133-3,802)]. The incidence of all life-threatening events was 2.1 % [95 % confidence interval (CI) 1.8-2.4 %], whereas mortality was 0.28 % (95 % CI 0.18-0.41 %). Fifty-seven life-threatening events required cardiopulmonary resuscitation, whereas 9 % required extracorporeal membrane oxygenation. Use of a risk adjustment model showed that age <1 year [odd ratio (OR) 1.9, 95 % CI 1.4-2.7, p < 0.001], hemodynamic vulnerability (OR 1.6, 95 % CI 1.1-2.3, p < 0.01), and procedure risk (category 3: OR 2.3, 95 % CI 1.3-4.1; category 4: OR 4.2, 95 % CI 2.4-7.4) were predictors of life-threatening events. Using this model, standardized life-threatening event ratios were calculated, thus showing that one institution had a life-threatening event rate greater than expected. Congenital cardiac catheterization and intervention can be performed safely with a low rate of life-threatening events and mortality; preprocedural evaluation of risk may optimize preparation of emergency rescue and bailout procedures. Risk predictors (age < 1, hemodynamic vulnerability, and procedure risk category) can enhance preprocedural patient risk stratification and planning.

Original languageEnglish
Pages (from-to)140-148
Number of pages9
JournalPediatric Cardiology
Issue number1
StatePublished - Jan 2014


  • Cardiac catheterization and intervention
  • Cardiac surgery
  • Congenital heart disease
  • ECMO
  • Mortality


Dive into the research topics of 'Incidence and management of life-threatening adverse events during cardiac catheterization for congenital heart disease'. Together they form a unique fingerprint.

Cite this