Inbred mouse strains differ in sensitivity to 'popping' behavior elicited by MK-801

Stephen I. Deutsch; Richard B. Rosse; Steven M. Paul; Raine L. Riggs; John Mastropaolo

doi:10.1016/S0091-3057(96)00347-4

Inbred mouse strains differ in sensitivity to 'popping' behavior elicited by MK-801

Stephen I. Deutsch, Richard B. Rosse, Steven M. Paul, Raine L. Riggs, John Mastropaolo

Washington University School of Medicine

Research output: Contribution to journal › Article › peer-review

46 Scopus citations

Abstract

We examined possible genetic contributions to MK-801-elicited 'popping' behavior in mice. MK-801 elicited 'popping' behavior may represent a preclinical screening paradigm for identifying novel antipsychotic medications. Specifically, we studied the sensitivity of four inbred strains of mice (BALB/c, C57BL/6, AKR, and DBA/2) to Mk-801-elicited 'popping' behavior and compared their response to the outbred NIH Swiss strain in which the behavior was first characterized. The BALB/c strain was most sensitive to the elicitation of MK-801 induced popping behavior, whereas the other inbred strains were less sensitive than the outbred strain. The identification of strain differences in MK-801-elicited 'popping' behavior suggests an important role for genetic factors in the elicitation of MK-801 'popping' behavior in mice.

Original language	English
Pages (from-to)	315-317
Number of pages	3
Journal	Pharmacology Biochemistry and Behavior
Volume	57
Issue number	1-2
DOIs	https://doi.org/10.1016/S0091-3057(96)00347-4
State	Published - May 1997

Keywords

MK-801
Mouse strains
NMDA receptor
Phencyclidine
Popping behavior
Schizophrenia

Access to Document

10.1016/S0091-3057(96)00347-4

Cite this

@article{99f02b4f0ed24cbe80ea6ed2ee5e4025,

title = "Inbred mouse strains differ in sensitivity to 'popping' behavior elicited by MK-801",

abstract = "We examined possible genetic contributions to MK-801-elicited 'popping' behavior in mice. MK-801 elicited 'popping' behavior may represent a preclinical screening paradigm for identifying novel antipsychotic medications. Specifically, we studied the sensitivity of four inbred strains of mice (BALB/c, C57BL/6, AKR, and DBA/2) to Mk-801-elicited 'popping' behavior and compared their response to the outbred NIH Swiss strain in which the behavior was first characterized. The BALB/c strain was most sensitive to the elicitation of MK-801 induced popping behavior, whereas the other inbred strains were less sensitive than the outbred strain. The identification of strain differences in MK-801-elicited 'popping' behavior suggests an important role for genetic factors in the elicitation of MK-801 'popping' behavior in mice.",

keywords = "MK-801, Mouse strains, NMDA receptor, Phencyclidine, Popping behavior, Schizophrenia",

author = "Deutsch, {Stephen I.} and Rosse, {Richard B.} and Paul, {Steven M.} and Riggs, {Raine L.} and John Mastropaolo",

note = "Funding Information: This work was supported by a grant from the Department of Veterans Affairs to SID.",

year = "1997",

month = may,

doi = "10.1016/S0091-3057(96)00347-4",

language = "English",

volume = "57",

pages = "315--317",

journal = "Pharmacology Biochemistry and Behavior",

issn = "0091-3057",

number = "1-2",

}

TY - JOUR

T1 - Inbred mouse strains differ in sensitivity to 'popping' behavior elicited by MK-801

AU - Deutsch, Stephen I.

AU - Rosse, Richard B.

AU - Paul, Steven M.

AU - Riggs, Raine L.

AU - Mastropaolo, John

N1 - Funding Information: This work was supported by a grant from the Department of Veterans Affairs to SID.

PY - 1997/5

Y1 - 1997/5

N2 - We examined possible genetic contributions to MK-801-elicited 'popping' behavior in mice. MK-801 elicited 'popping' behavior may represent a preclinical screening paradigm for identifying novel antipsychotic medications. Specifically, we studied the sensitivity of four inbred strains of mice (BALB/c, C57BL/6, AKR, and DBA/2) to Mk-801-elicited 'popping' behavior and compared their response to the outbred NIH Swiss strain in which the behavior was first characterized. The BALB/c strain was most sensitive to the elicitation of MK-801 induced popping behavior, whereas the other inbred strains were less sensitive than the outbred strain. The identification of strain differences in MK-801-elicited 'popping' behavior suggests an important role for genetic factors in the elicitation of MK-801 'popping' behavior in mice.

AB - We examined possible genetic contributions to MK-801-elicited 'popping' behavior in mice. MK-801 elicited 'popping' behavior may represent a preclinical screening paradigm for identifying novel antipsychotic medications. Specifically, we studied the sensitivity of four inbred strains of mice (BALB/c, C57BL/6, AKR, and DBA/2) to Mk-801-elicited 'popping' behavior and compared their response to the outbred NIH Swiss strain in which the behavior was first characterized. The BALB/c strain was most sensitive to the elicitation of MK-801 induced popping behavior, whereas the other inbred strains were less sensitive than the outbred strain. The identification of strain differences in MK-801-elicited 'popping' behavior suggests an important role for genetic factors in the elicitation of MK-801 'popping' behavior in mice.

KW - MK-801

KW - Mouse strains

KW - NMDA receptor

KW - Phencyclidine

KW - Popping behavior

KW - Schizophrenia

UR - http://www.scopus.com/inward/record.url?scp=0030983012&partnerID=8YFLogxK

U2 - 10.1016/S0091-3057(96)00347-4

DO - 10.1016/S0091-3057(96)00347-4

M3 - Article

C2 - 9164588

AN - SCOPUS:0030983012

SN - 0091-3057

VL - 57

SP - 315

EP - 317

JO - Pharmacology Biochemistry and Behavior

JF - Pharmacology Biochemistry and Behavior

IS - 1-2

ER -

Inbred mouse strains differ in sensitivity to 'popping' behavior elicited by MK-801

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this