Inbred mouse strains differ in sensitivity to 'popping' behavior elicited by MK-801

Stephen I. Deutsch, Richard B. Rosse, Steven M. Paul, Raine L. Riggs, John Mastropaolo

Research output: Contribution to journalArticle

43 Scopus citations

Abstract

We examined possible genetic contributions to MK-801-elicited 'popping' behavior in mice. MK-801 elicited 'popping' behavior may represent a preclinical screening paradigm for identifying novel antipsychotic medications. Specifically, we studied the sensitivity of four inbred strains of mice (BALB/c, C57BL/6, AKR, and DBA/2) to Mk-801-elicited 'popping' behavior and compared their response to the outbred NIH Swiss strain in which the behavior was first characterized. The BALB/c strain was most sensitive to the elicitation of MK-801 induced popping behavior, whereas the other inbred strains were less sensitive than the outbred strain. The identification of strain differences in MK-801-elicited 'popping' behavior suggests an important role for genetic factors in the elicitation of MK-801 'popping' behavior in mice.

Original languageEnglish
Pages (from-to)315-317
Number of pages3
JournalPharmacology Biochemistry and Behavior
Volume57
Issue number1-2
DOIs
StatePublished - May 1 1997
Externally publishedYes

Keywords

  • MK-801
  • Mouse strains
  • NMDA receptor
  • Phencyclidine
  • Popping behavior
  • Schizophrenia

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