Inactivated seasonal influenza vaccines increase serum antibodies to the neuraminidase of pandemic influenza A(H1N1) 2009 virus in an age-dependent manner

Glendie Marcelin, Hilliary M. Bland, Nicholas J. Negovetich, Matthew R. Sandbulte, Ali H. Ellebedy, Ashley D. Webb, Yolanda S. Griffin, Jennifer L. DeBeauchamp, Janet E. McElhaney, Richard J. Webby

Research output: Contribution to journalArticlepeer-review

44 Scopus citations

Abstract

Levels of preexisting antibodies to the hemagglutinin of pandemic influenza A(H1N1) 2009 (hereafter pandemic H1N1) virus positively correlate with age. The impact of contemporary seasonal influenza vaccines on establishing immunity to other pandemic H1N1 proteins is unknown. We measured serum antibodies to the neuraminidase (NA) of pandemic H1N1 in adults prior to and after vaccination with seasonal trivalent inactivated influenza vaccines. Serum antibodies to pandemic H1N1 NA were observed in all age groups; however, vaccination elevated levels of pandemic H1N1 NA antibodies predominately in elderly individuals (age, ≥60 years). Therefore, contemporary seasonal vaccines likely contribute to reduction of pandemic H1N1-associated disease in older individuals.

Original languageEnglish
Pages (from-to)1634-1638
Number of pages5
JournalJournal of Infectious Diseases
Volume202
Issue number11
DOIs
StatePublished - Dec 1 2010

Fingerprint

Dive into the research topics of 'Inactivated seasonal influenza vaccines increase serum antibodies to the neuraminidase of pandemic influenza A(H1N1) 2009 virus in an age-dependent manner'. Together they form a unique fingerprint.

Cite this