TY - JOUR
T1 - Inactivated seasonal influenza vaccines increase serum antibodies to the neuraminidase of pandemic influenza A(H1N1) 2009 virus in an age-dependent manner
AU - Marcelin, Glendie
AU - Bland, Hilliary M.
AU - Negovetich, Nicholas J.
AU - Sandbulte, Matthew R.
AU - Ellebedy, Ali H.
AU - Webb, Ashley D.
AU - Griffin, Yolanda S.
AU - DeBeauchamp, Jennifer L.
AU - McElhaney, Janet E.
AU - Webby, Richard J.
N1 - Funding Information:
Received 23 March 2010; accepted 23 June 2010; electronically published 27 October 2010. Potential conflicts of interest: none reported. Financial support: National Institute of Allergy and Infectious Diseases (contract HHSN266200700005C and grant R01 AI68265); Canadian Institutes of Health Research; American Lebanese Syrian Associated Charities; GlaxoSmithKline (investigator-initiated contract to J.E.M.). a Present affiliations: Mississippi Valley State University, Itta Bena, Mississippi (H.M.B.); Department of Environmental Health and Safety, University of Mississippi Medical Center, Jackson (Y.S.G.). Reprints or correspondence: Dr Richard J. Webby, Department of Infectious Diseases, St Jude Children’s Research Hospital, 262 Danny Thomas Pl, Mail Stop 330, Memphis, TN 38105 ([email protected]).
PY - 2010/12/1
Y1 - 2010/12/1
N2 - Levels of preexisting antibodies to the hemagglutinin of pandemic influenza A(H1N1) 2009 (hereafter pandemic H1N1) virus positively correlate with age. The impact of contemporary seasonal influenza vaccines on establishing immunity to other pandemic H1N1 proteins is unknown. We measured serum antibodies to the neuraminidase (NA) of pandemic H1N1 in adults prior to and after vaccination with seasonal trivalent inactivated influenza vaccines. Serum antibodies to pandemic H1N1 NA were observed in all age groups; however, vaccination elevated levels of pandemic H1N1 NA antibodies predominately in elderly individuals (age, ≥60 years). Therefore, contemporary seasonal vaccines likely contribute to reduction of pandemic H1N1-associated disease in older individuals.
AB - Levels of preexisting antibodies to the hemagglutinin of pandemic influenza A(H1N1) 2009 (hereafter pandemic H1N1) virus positively correlate with age. The impact of contemporary seasonal influenza vaccines on establishing immunity to other pandemic H1N1 proteins is unknown. We measured serum antibodies to the neuraminidase (NA) of pandemic H1N1 in adults prior to and after vaccination with seasonal trivalent inactivated influenza vaccines. Serum antibodies to pandemic H1N1 NA were observed in all age groups; however, vaccination elevated levels of pandemic H1N1 NA antibodies predominately in elderly individuals (age, ≥60 years). Therefore, contemporary seasonal vaccines likely contribute to reduction of pandemic H1N1-associated disease in older individuals.
UR - http://www.scopus.com/inward/record.url?scp=78649597615&partnerID=8YFLogxK
U2 - 10.1086/657084
DO - 10.1086/657084
M3 - Article
C2 - 20979454
AN - SCOPUS:78649597615
SN - 0022-1899
VL - 202
SP - 1634
EP - 1638
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 11
ER -