In vivo whole-brain T1-rho mapping across adulthood: Normative values and age dependence

Richard Watts, Trevor Andrews, Scott Hipko, Jay V. Gonyea, Christopher G. Filippi

Research output: Contribution to journalArticle

17 Scopus citations


Purpose To report a systematic investigation of variations in brain T (T1-rho) values over adulthood, and present normative values for cortical gray matter, juxtacortical white matter, selected white matter tracts and subcortical structures. Materials and Methods Forty-one healthy control subjects (23 males aged 18-76 years and 18 females aged 21-73 years) were imaged at 3.0 Tesla (T) using a novel whole-brain T- weighted fluid suppressed three-dimensional turbo spin echo technique. T maps were calculated and atlas-based segmentation used to determine regional T values. Linear regression was used to determine changes in T with age. Results T values showed significant decreases with age in cortical gray matter (P < 0.001), left and right caudate (P = 0.004/0.006), putamen (P = 0.001, P < 0.001), hippocampus (P = 0.039/0.010), amygdala (P = 0.002/0.001), and nucleus accumbens (P = 0.001/0.002). Significant increases with age (P < 0.05) were observed in all the white matter tracts considered, except the corticospinal tracts and forceps major. Conclusion T demonstrates changes related to the processes of normal aging.

Original languageEnglish
Pages (from-to)376-382
Number of pages7
JournalJournal of Magnetic Resonance Imaging
Issue number2
StatePublished - Aug 2014
Externally publishedYes


  • MRI
  • aging
  • brain
  • spin-lock

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