TY - GEN
T1 - In vivo ultrasonic detection of angiogenesis with site-targeted nanoparticle contrast agents using measure-theoretic signal receivers
AU - Hughes, M. S.
AU - Marsh, J. N.
AU - Allen, J.
AU - Brown, P. A.
AU - Lacy, E. K.
AU - Scott, M. J.
AU - Lanza, G. M.
AU - Wickline, S. A.
AU - Hall, C. S.
N1 - Copyright:
Copyright 2012 Elsevier B.V., All rights reserved.
PY - 2004
Y1 - 2004
N2 - Angiogenesis has been postulated as an important marker for the early detection of cancer. The proteins associated with new vessels are sub-resolution for ultrasonic imaging, necessitating the use of contrast agents. In this work we use a liquid, perfluorocarbon nanoparticle previously shown to enhance specific targets in in vitro and in situ settings. Previous studies focused on the use of conventional signal analysis techniques including signal amplitude, signal energy, and spectral analysis. To explore the possibility of further increasing contrast between targeted bio-markers and untargeted tissue, we applied concepts from measure-theoretic (e.g., information theory, thermodynamics) and topological dynamics. Specifically, Shannon Entropy, H s, its continuous limit, H c, and three quantities obtained using analogies with thermodynamics: C v,E th, which have been described elsewhere[1-6). We describe the outcome of employing these types of dynamical quantities to ultrasonic data acquired in vivo using New Zealand White Rabbits implanted with VX2-tumors and then exposed over the course of two hours to α v,β 3 integrin-targeted liquid perfluorocarbon nanoparticles.
AB - Angiogenesis has been postulated as an important marker for the early detection of cancer. The proteins associated with new vessels are sub-resolution for ultrasonic imaging, necessitating the use of contrast agents. In this work we use a liquid, perfluorocarbon nanoparticle previously shown to enhance specific targets in in vitro and in situ settings. Previous studies focused on the use of conventional signal analysis techniques including signal amplitude, signal energy, and spectral analysis. To explore the possibility of further increasing contrast between targeted bio-markers and untargeted tissue, we applied concepts from measure-theoretic (e.g., information theory, thermodynamics) and topological dynamics. Specifically, Shannon Entropy, H s, its continuous limit, H c, and three quantities obtained using analogies with thermodynamics: C v,E th, which have been described elsewhere[1-6). We describe the outcome of employing these types of dynamical quantities to ultrasonic data acquired in vivo using New Zealand White Rabbits implanted with VX2-tumors and then exposed over the course of two hours to α v,β 3 integrin-targeted liquid perfluorocarbon nanoparticles.
KW - Information-theory
KW - Signal receiver
KW - Thermodynamic analog
UR - http://www.scopus.com/inward/record.url?scp=21644474176&partnerID=8YFLogxK
U2 - 10.1109/ULTSYM.2004.1417973
DO - 10.1109/ULTSYM.2004.1417973
M3 - Conference contribution
AN - SCOPUS:21644474176
SN - 0780384121
T3 - Proceedings - IEEE Ultrasonics Symposium
SP - 1106
EP - 1109
BT - Proceedings - 2004 IEEE Ultrasonics Symposium
A2 - Yuhas, M.P.
T2 - 2004 IEEE Ultrasonics Symposium
Y2 - 23 August 2004 through 27 August 2004
ER -