In vivo T-cell activation by a monoclonal αCD3ε antibody induces preterm labor and birth

Nardhy Gomez-Lopez, Roberto Romero, Marcia Arenas-Hernandez, Hyunyoung Ahn, Bogdan Panaitescu, Felipe Vadillo-Ortega, Carmen Sanchez-Torres, Katherine S. Salisbury, Sonia S. Hassan

Research output: Contribution to journalArticlepeer-review

36 Scopus citations

Abstract

Problem: Activated/effector T cells seem to play a role in the pathological inflammation associated with preterm labor. The aim of this study was to determine whether in vivo T-cell activation by a monoclonal αCD3ε antibody induces preterm labor and birth. Method of study: Pregnant B6 mice were intraperitoneally injected with a monoclonal αCD3ε antibody or its isotype control. The gestational age, the rates of preterm birth and pup mortality at birth as well as the fetal heart rate and umbilical artery pulsatility index were determined. Results: Injection of a monoclonal αCD3ε antibody led to preterm labor/birth (αCD3ε 83 ± 16.97% [10/12] vs isotype 0% [0/8]) and increased the rate of pup mortality at birth (αCD3ε 87.30 ± 8.95% [77/85] vs isotype 4.91 ± 4.34% [3/59]). In addition, injection of a monoclonal αCD3ε antibody decreased the fetal heart rate and increased the umbilical artery pulsatility index when compared to the isotype control. Conclusion: In vivo T-cell activation by a monoclonal αCD3ε antibody in late gestation induces preterm labor and birth.

Original languageEnglish
Pages (from-to)386-390
Number of pages5
JournalAmerican Journal of Reproductive Immunology
Volume76
Issue number5
DOIs
StatePublished - Nov 1 2016

Keywords

  • adaptive immunity
  • cytokines
  • maternal–fetal rejection
  • mouse
  • parturition
  • pregnancy
  • T cells

Fingerprint

Dive into the research topics of 'In vivo T-cell activation by a monoclonal αCD3ε antibody induces preterm labor and birth'. Together they form a unique fingerprint.

Cite this