In vivo studies of [125I]iodobenzamide and [11C]iodobenzamide: A ligand suitable for positron emission tomography and single photon emission tomography imaging of cerebral D2 dopamine receptors

Dean F. Wong; Alan A. Wilson; Catherine Chen; Elynne Minkin; Robert F. Dannals; Hayden T. Ravert; Patricia Sanchez‐Roa; Victor Villemagne; Henry N. Wagner

doi:10.1002/syn.890120309

In vivo studies of [¹²⁵I]iodobenzamide and [¹¹C]iodobenzamide: A ligand suitable for positron emission tomography and single photon emission tomography imaging of cerebral D₂ dopamine receptors

Dean F. Wong, Alan A. Wilson, Catherine Chen, Elynne Minkin, Robert F. Dannals, Hayden T. Ravert, Patricia Sanchez‐Roa, Victor Villemagne, Henry N. Wagner

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Abstract

Iodobenzamide (IMB) labeled with either [¹¹C] or [¹²⁵I] was studied in mice and baboons. Pharmacological studies demonstrated an in vivo binding profile compatible with D₂ dopamine receptors. Mouse biodistribution studies with both [¹¹C]IMB and [¹²⁵I]IMB showed a similar brain distribution of radioactivity. Mouse [¹²⁵I]IMB studies with amphetamine and reserpine pretreatment suggested that IMB may be less susceptible to endogenous dopamine competition for D₂ receptor binding in vivo as compared to raclopride. Preliminary baboon studies showed haloperidol competition for IMB binding sites. © 1992 Wiley‐Liss, Inc.

Original language	English
Pages (from-to)	236-241
Number of pages	6
Journal	Synapse
Volume	12
Issue number	3
DOIs	https://doi.org/10.1002/syn.890120309
State	Published - Nov 1992

Keywords

Endogenous dopamine
In vivo biodistribution
Radioactivity

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10.1002/syn.890120309

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Wong, D. F., Wilson, A. A., Chen, C., Minkin, E., Dannals, R. F., Ravert, H. T., Sanchez‐Roa, P., Villemagne, V., & Wagner, H. N. (1992). In vivo studies of [¹²⁵I]iodobenzamide and [¹¹C]iodobenzamide: A ligand suitable for positron emission tomography and single photon emission tomography imaging of cerebral D₂ dopamine receptors. Synapse, 12(3), 236-241. https://doi.org/10.1002/syn.890120309

@article{f16f4dc180914d9b91bc0f5ef9f47758,

title = "In vivo studies of [125I]iodobenzamide and [11C]iodobenzamide: A ligand suitable for positron emission tomography and single photon emission tomography imaging of cerebral D2 dopamine receptors",

abstract = "Iodobenzamide (IMB) labeled with either [11C] or [125I] was studied in mice and baboons. Pharmacological studies demonstrated an in vivo binding profile compatible with D2 dopamine receptors. Mouse biodistribution studies with both [11C]IMB and [125I]IMB showed a similar brain distribution of radioactivity. Mouse [125I]IMB studies with amphetamine and reserpine pretreatment suggested that IMB may be less susceptible to endogenous dopamine competition for D2 receptor binding in vivo as compared to raclopride. Preliminary baboon studies showed haloperidol competition for IMB binding sites. {\textcopyright} 1992 Wiley‐Liss, Inc.",

keywords = "Endogenous dopamine, In vivo biodistribution, Radioactivity",

author = "Wong, {Dean F.} and Wilson, {Alan A.} and Catherine Chen and Elynne Minkin and Dannals, {Robert F.} and Ravert, {Hayden T.} and Patricia Sanchez‐Roa and Victor Villemagne and Wagner, {Henry N.}",

year = "1992",

month = nov,

doi = "10.1002/syn.890120309",

language = "English",

volume = "12",

pages = "236--241",

journal = "Synapse",

issn = "0887-4476",

number = "3",

}

Wong, DF, Wilson, AA, Chen, C, Minkin, E, Dannals, RF, Ravert, HT, Sanchez‐Roa, P, Villemagne, V & Wagner, HN 1992, 'In vivo studies of [¹²⁵I]iodobenzamide and [¹¹C]iodobenzamide: A ligand suitable for positron emission tomography and single photon emission tomography imaging of cerebral D₂ dopamine receptors', Synapse, vol. 12, no. 3, pp. 236-241. https://doi.org/10.1002/syn.890120309

TY - JOUR

T1 - In vivo studies of [125I]iodobenzamide and [11C]iodobenzamide

T2 - A ligand suitable for positron emission tomography and single photon emission tomography imaging of cerebral D2 dopamine receptors

AU - Wong, Dean F.

AU - Wilson, Alan A.

AU - Chen, Catherine

AU - Minkin, Elynne

AU - Dannals, Robert F.

AU - Ravert, Hayden T.

AU - Sanchez‐Roa, Patricia

AU - Villemagne, Victor

AU - Wagner, Henry N.

PY - 1992/11

Y1 - 1992/11

N2 - Iodobenzamide (IMB) labeled with either [11C] or [125I] was studied in mice and baboons. Pharmacological studies demonstrated an in vivo binding profile compatible with D2 dopamine receptors. Mouse biodistribution studies with both [11C]IMB and [125I]IMB showed a similar brain distribution of radioactivity. Mouse [125I]IMB studies with amphetamine and reserpine pretreatment suggested that IMB may be less susceptible to endogenous dopamine competition for D2 receptor binding in vivo as compared to raclopride. Preliminary baboon studies showed haloperidol competition for IMB binding sites. © 1992 Wiley‐Liss, Inc.

AB - Iodobenzamide (IMB) labeled with either [11C] or [125I] was studied in mice and baboons. Pharmacological studies demonstrated an in vivo binding profile compatible with D2 dopamine receptors. Mouse biodistribution studies with both [11C]IMB and [125I]IMB showed a similar brain distribution of radioactivity. Mouse [125I]IMB studies with amphetamine and reserpine pretreatment suggested that IMB may be less susceptible to endogenous dopamine competition for D2 receptor binding in vivo as compared to raclopride. Preliminary baboon studies showed haloperidol competition for IMB binding sites. © 1992 Wiley‐Liss, Inc.

KW - Endogenous dopamine

KW - In vivo biodistribution

KW - Radioactivity

UR - http://www.scopus.com/inward/record.url?scp=0026614585&partnerID=8YFLogxK

U2 - 10.1002/syn.890120309

DO - 10.1002/syn.890120309

M3 - Article

C2 - 1481143

AN - SCOPUS:0026614585

SN - 0887-4476

VL - 12

SP - 236

EP - 241

JO - Synapse

JF - Synapse

IS - 3

ER -

In vivo studies of [¹²⁵I]iodobenzamide and [¹¹C]iodobenzamide: A ligand suitable for positron emission tomography and single photon emission tomography imaging of cerebral D₂ dopamine receptors

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