In vivo quantification of T1, T2, and apparent diffusion coefficient in the mouse retina at 11.74T

Junjie Chen, Qing Wang, Huiying Zhang, Xiaoxia Yang, Jian Wang, Bruce A. Berkowitz, Samuel A. Wickline, Sheng Kwei Song

Research output: Contribution to journalArticle

38 Scopus citations

Abstract

MRI has recently been used for noninvasive examination of retinal structure and function in rats and cats. However, the advantages of quantitative high-resolution MRI of retina from mice have not yet been explored. In the present study, T1 and T2 relaxation time constants and the directional apparent diffusion coefficient (ADC) in the retina of C57/BL6 mice were measured. Three MR-detected retina layers and a MR-detected choroid layer were observed on both T1- and T2-weighted images at an image resolution of 47 x 47 x 400 μm3. The significantly higher ADC parallel to than that perpendicular to the optic nerve in the MR-detected outer retina layer at the central retina reflects the known cellular organization of the photoreceptor cells. This study establishes, for the first time, normative metrics of T1, T2, and ADC of the mouse retina. These MR parameters are expected to be useful in future evaluation of developmental and pathological alterations of retinal cell layers in mice.

Original languageEnglish
Pages (from-to)731-738
Number of pages8
JournalMagnetic resonance in medicine
Volume59
Issue number4
DOIs
StatePublished - Apr 1 2008

Keywords

  • Apparent diffusion coefficient
  • MRI
  • Mice
  • Retina
  • T relaxation time constant
  • T relaxation time constant

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