In Vivo Intravascular Ultrasound-Based 3D Thin-Walled Model for Human Coronary Plaque Progression Study: Transforming Research to Potential Commercialization

Jian Guo, Liang Wang, David Monoly, Habib Samady, Jie Zheng, Xiaoya Guo, Akiko Maehara, Gary S. Mintz, Jian Zhu, Genshan Ma, Dalin Tang

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Cardiovascular disease (CVD) is the leading cause of death in the world. Considerable research has been done linking various mechanical risk factors to plaque progression and rupture. However, methods transforming research results to clinical implementation are limited by time-consuming processes. In this study, a 3D thin-wall (TW) model was developed to approximate the 3D fluid-structure interaction (FSI) model to save time for clinical implementations. Results from one patient data (100 TW models) indicated that the relative errors of the average plaque wall stress (APWS) and strain were less than 7%, meanwhile the correlation results of the TW models were similar with that of the FSI models.

Original languageEnglish
Article number1842011
JournalInternational Journal of Computational Methods
Volume16
Issue number3
DOIs
StatePublished - May 1 2019

Keywords

  • Coronary
  • IVUS
  • fluid-structure interactions
  • plaque progression
  • vulnerable plaque

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