In vivo fluorescence reflectance imaging with subcutaneous mouse tumor models

Jie Cao, Mingzhou Zhou

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

2 Scopus citations


Optical imaging is undoubtedly one of the most versatile and widely used imaging techniques in both research and clinical practice. Among optical imaging technologies, fluorescence imaging is the most popularly used and has become an essential tool in biomedical science. A key component of fluorescence imaging is fluorescence-producing reporters, including fluorescent dyes and conjugates, as well as fluorescent proteins. For in vivo imaging applications, fluorophores with long emission at the near-infrared (NIR) region are generally preferred to overcome the photon attenuation in living tissue. Here, we describe the in vivo fluorescence imaging of an integrin αυ β3 targeted NIR fluorescent probe (cRGD-ICG-Der-02) using subcutaneous mouse tumor models.

Original languageEnglish
Title of host publicationMethods in Molecular Biology
PublisherHumana Press Inc.
Number of pages9
StatePublished - 2016

Publication series

NameMethods in Molecular Biology
ISSN (Print)1064-3745


  • ICG
  • In vivo
  • Near infrared fluorescence imaging
  • Noninvasive
  • Tumor targeting probe


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