In vivo evolution of biopsy-proven inflammatory demyelination quantified by R2t* mapping

Biao Xiang; Jie Wen; Hsiang Chih Lu; Robert E. Schmidt; Dmitriy A. Yablonskiy; Anne H. Cross

doi:10.1002/acn3.51052

In vivo evolution of biopsy-proven inflammatory demyelination quantified by R2t* mapping

Biao Xiang, Jie Wen, Hsiang Chih Lu, Robert E. Schmidt, Dmitriy A. Yablonskiy, Anne H. Cross

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6 Scopus citations

Abstract

A 35-year-old man with an enhancing tumefactive brain lesion underwent biopsy, revealing inflammatory demyelination. We used quantitative Gradient-Recalled-Echo (qGRE) MRI to visualize and measure tissue damage in the lesion. Two weeks after biopsy, qGRE showed significant R2t* reduction in the left optic radiation and surrounding tissue, consistent with the histopathological and clinical findings. qGRE was repeated 6 and 14 months later, demonstrating partially recovered optic radiation R2t*, in concert with improvement of the hemianopia to ultimately involve only the lower right visual quadrant. These results support qGRE metrics as in vivo biomarkers for tissue damage and longitudinal monitoring of demyelinating disease.

Original language	English
Pages (from-to)	1055-1060
Number of pages	6
Journal	Annals of Clinical and Translational Neurology
Volume	7
Issue number	6
DOIs	https://doi.org/10.1002/acn3.51052
State	Published - Jun 1 2020

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title = "In vivo evolution of biopsy-proven inflammatory demyelination quantified by R2t* mapping",

abstract = "A 35-year-old man with an enhancing tumefactive brain lesion underwent biopsy, revealing inflammatory demyelination. We used quantitative Gradient-Recalled-Echo (qGRE) MRI to visualize and measure tissue damage in the lesion. Two weeks after biopsy, qGRE showed significant R2t* reduction in the left optic radiation and surrounding tissue, consistent with the histopathological and clinical findings. qGRE was repeated 6 and 14 months later, demonstrating partially recovered optic radiation R2t*, in concert with improvement of the hemianopia to ultimately involve only the lower right visual quadrant. These results support qGRE metrics as in vivo biomarkers for tissue damage and longitudinal monitoring of demyelinating disease.",

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AU - Wen, Jie

AU - Lu, Hsiang Chih

AU - Schmidt, Robert E.

AU - Yablonskiy, Dmitriy A.

AU - Cross, Anne H.

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AB - A 35-year-old man with an enhancing tumefactive brain lesion underwent biopsy, revealing inflammatory demyelination. We used quantitative Gradient-Recalled-Echo (qGRE) MRI to visualize and measure tissue damage in the lesion. Two weeks after biopsy, qGRE showed significant R2t* reduction in the left optic radiation and surrounding tissue, consistent with the histopathological and clinical findings. qGRE was repeated 6 and 14 months later, demonstrating partially recovered optic radiation R2t*, in concert with improvement of the hemianopia to ultimately involve only the lower right visual quadrant. These results support qGRE metrics as in vivo biomarkers for tissue damage and longitudinal monitoring of demyelinating disease.

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In vivo evolution of biopsy-proven inflammatory demyelination quantified by R2t* mapping

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