In vivo developmental stages in murine natural killer cell maturation

Sungjin Kim; Koho Iizuka; Hyun Seok P. Kang; Ayontunde Dokun; Anthony R. French; Suellen Greco; Wayne M. Yokoyama

doi:10.1038/ni796

In vivo developmental stages in murine natural killer cell maturation

Sungjin Kim, Koho Iizuka, Hyun Seok P. Kang, Ayontunde Dokun, Anthony R. French, Suellen Greco, Wayne M. Yokoyama

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506 Scopus citations

Abstract

Natural killer (NK) cells develop in the bone marrow, but their in vivo stages of maturation, expansion and acquisition of receptors that guide target cell specificity are not well defined. We describe here such stages of development. We also show that developing NK cells actively proliferate at a phenotypically distinguishable immature stage after they have acquired expression of Ly49 and CD94-NKG2 receptors. These studies provide a developmental framework for NK cell maturation in vivo and suggest the possible involvement of the Ly49 and CD94-NKG2 receptors themselves in modulating expansion of NK cell populations with a given NK cell receptor repertoire.

Original language	English
Pages (from-to)	523-528
Number of pages	6
Journal	Nature immunology
Volume	3
Issue number	6
DOIs	https://doi.org/10.1038/ni796
State	Published - 2002

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title = "In vivo developmental stages in murine natural killer cell maturation",

abstract = "Natural killer (NK) cells develop in the bone marrow, but their in vivo stages of maturation, expansion and acquisition of receptors that guide target cell specificity are not well defined. We describe here such stages of development. We also show that developing NK cells actively proliferate at a phenotypically distinguishable immature stage after they have acquired expression of Ly49 and CD94-NKG2 receptors. These studies provide a developmental framework for NK cell maturation in vivo and suggest the possible involvement of the Ly49 and CD94-NKG2 receptors themselves in modulating expansion of NK cell populations with a given NK cell receptor repertoire.",

author = "Sungjin Kim and Koho Iizuka and Kang, {Hyun Seok P.} and Ayontunde Dokun and French, {Anthony R.} and Suellen Greco and Yokoyama, {Wayne M.}",

note = "Funding Information: Acknowledgments Supported by the Howard Hughes Medical Institute, Barnes-Jewish Hospital Foundation and NIH grants to W. M.Y. We thank M. Colonna and E. Ho for critical reading of this manuscript and Y.-J. Song, D. Higuchi, K. Marlotte, and J. Laurent for technical support.",

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doi = "10.1038/ni796",

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T1 - In vivo developmental stages in murine natural killer cell maturation

AU - Kim, Sungjin

AU - Iizuka, Koho

AU - Kang, Hyun Seok P.

AU - Dokun, Ayontunde

AU - French, Anthony R.

AU - Greco, Suellen

AU - Yokoyama, Wayne M.

N1 - Funding Information: Acknowledgments Supported by the Howard Hughes Medical Institute, Barnes-Jewish Hospital Foundation and NIH grants to W. M.Y. We thank M. Colonna and E. Ho for critical reading of this manuscript and Y.-J. Song, D. Higuchi, K. Marlotte, and J. Laurent for technical support.

PY - 2002

Y1 - 2002

N2 - Natural killer (NK) cells develop in the bone marrow, but their in vivo stages of maturation, expansion and acquisition of receptors that guide target cell specificity are not well defined. We describe here such stages of development. We also show that developing NK cells actively proliferate at a phenotypically distinguishable immature stage after they have acquired expression of Ly49 and CD94-NKG2 receptors. These studies provide a developmental framework for NK cell maturation in vivo and suggest the possible involvement of the Ly49 and CD94-NKG2 receptors themselves in modulating expansion of NK cell populations with a given NK cell receptor repertoire.

AB - Natural killer (NK) cells develop in the bone marrow, but their in vivo stages of maturation, expansion and acquisition of receptors that guide target cell specificity are not well defined. We describe here such stages of development. We also show that developing NK cells actively proliferate at a phenotypically distinguishable immature stage after they have acquired expression of Ly49 and CD94-NKG2 receptors. These studies provide a developmental framework for NK cell maturation in vivo and suggest the possible involvement of the Ly49 and CD94-NKG2 receptors themselves in modulating expansion of NK cell populations with a given NK cell receptor repertoire.

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DO - 10.1038/ni796

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SN - 1529-2908

VL - 3

SP - 523

EP - 528

JO - Nature immunology

JF - Nature immunology

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In vivo developmental stages in murine natural killer cell maturation

Abstract

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