In vivo characterization of emerging white matter microstructure in the fetal brain in the third trimester

Camilo Jaimes, Fedel Machado-Rivas, Onur Afacan, Shadab Khan, Bahram Marami, Cynthia M. Ortinau, Caitlin K. Rollins, Clemente Velasco-Annis, Simon K. Warfield, Ali Gholipour

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


The third trimester of pregnancy is a period of rapid development of fiber bundles in the fetal white matter. Using a recently developed motion-tracked slice-to-volume registration (MT-SVR) method, we aimed to quantify tract-specific developmental changes in apparent diffusion coefficient (ADC), fractional anisotropy (FA), and volume in third trimester healthy fetuses. To this end, we reconstructed diffusion tensor images from motion corrected fetal diffusion magnetic resonance imaging data. With an approved protocol, fetal MRI exams were performed on healthy pregnant women at 3 Tesla and included multiple (2–8) diffusion scans of the fetal head (1–2 b = 0 s/mm2 images and 12 diffusion-sensitized images at b = 500 s/mm2). Diffusion data from 32 fetuses (13 females) with median gestational age (GA) of 33 weeks 4 days were processed with MT-SVR and deterministic tractography seeded by regions of interest corresponding to 12 major fiber tracts. Multivariable regression analysis was used to evaluate the association of GA with volume, FA, and ADC for each tract. For all tracts, the volume and FA increased, and the ADC decreased with GA. Associations reached statistical significance for: FA and ADC of the forceps major; volume and ADC for the forceps minor; FA, ADC, and volume for the cingulum; ADC, FA, and volume for the uncinate fasciculi; ADC of the inferior fronto-occipital fasciculi, ADC of the inferior longitudinal fasciculi; and FA and ADC for the corticospinal tracts. These quantitative results demonstrate the complex pattern and rates of tract-specific, GA-related microstructural changes of the developing white matter in human fetal brain.

Original languageEnglish
Pages (from-to)3177-3185
Number of pages9
JournalHuman Brain Mapping
Issue number12
StatePublished - Aug 15 2020


  • developing white matter
  • diffusion tensor imaging
  • diffusion weighted MRI
  • fetal MRI
  • fetal brain
  • tract-specific analysis
  • tractography
  • white matter microstructure


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