In vivo characterization of connective tissue remodeling using infrared photoacoustic spectra

Yuan Qu; Peng Hu; Junhui Shi; Konstantin Maslov; Peinan Zhao; Chiye Li; Jun Ma; Alejandro Garcia-Uribe; Karen Meyers; Emily Diveley; Stephanie Pizzella; Lisa Muench; Nina Punyamurthy; Naomi Goldstein; Oji Onwumere; Mariana Alisio; Kaytelyn Meyenburg; Jennifer Maynard; Kristi Helm; Emma Altieri; Janessia Slaughter; Sabrina Barber; Tracy Burger; Christine Kramer; Jessica Chubiz; Monica Anderson; Ronald McCarthy; Sarah K. England; George A. Macones; Molly J. Stout; Methodius Tuuli; Lihong V. Wang

doi:10.1117/1.JBO.23.12.121621

In vivo characterization of connective tissue remodeling using infrared photoacoustic spectra

Yuan Qu, Peng Hu, Junhui Shi, Konstantin Maslov, Peinan Zhao, Chiye Li, Jun Ma, Alejandro Garcia-Uribe, Karen Meyers, Emily Diveley, Stephanie Pizzella, Lisa Muench, Nina Punyamurthy, Naomi Goldstein, Oji Onwumere, Mariana Alisio, Kaytelyn Meyenburg, Jennifer Maynard, Kristi Helm, Emma AltieriJanessia Slaughter, Sabrina Barber, Tracy Burger, Christine Kramer, Jessica Chubiz, Monica Anderson, Ronald McCarthy, Sarah K. England, George A. Macones, Molly J. Stout, Methodius Tuuli, Lihong V. Wang

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Premature cervical remodeling is a critical precursor of spontaneous preterm birth, and the remodeling process is characterized by an increase in tissue hydration. Nevertheless, current clinical measurements of cervical remodeling are subjective and detect only late events, such as cervical effacement and dilation. Here, we present a photoacoustic endoscope that can quantify tissue hydration by measuring near-infrared cervical spectra. We quantify the water contents of tissue-mimicking hydrogel phantoms as an analog of cervical connective tissue. Applying this method to pregnant women in vivo, we observed an increase in the water content of the cervix throughout pregnancy. The application of this technique in maternal healthcare may advance our understanding of cervical remodeling and provide a sensitive method for predicting preterm birth.

Original language	English
Article number	121621
Journal	Journal of biomedical optics
Volume	23
Issue number	12
DOIs	https://doi.org/10.1117/1.JBO.23.12.121621
State	Published - Dec 1 2018

Keywords

cervical examination
photoacoustic endoscopy
spectroscopy
tissue hydration

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10.1117/1.JBO.23.12.121621

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Qu, Y., Hu, P., Shi, J., Maslov, K., Zhao, P., Li, C., Ma, J., Garcia-Uribe, A., Meyers, K., Diveley, E., Pizzella, S., Muench, L., Punyamurthy, N., Goldstein, N., Onwumere, O., Alisio, M., Meyenburg, K., Maynard, J., Helm, K., ... Wang, L. V. (2018). In vivo characterization of connective tissue remodeling using infrared photoacoustic spectra. Journal of biomedical optics, 23(12), Article 121621. https://doi.org/10.1117/1.JBO.23.12.121621

@article{54b4bc7aa0764b269a6504bc23404acf,

title = "In vivo characterization of connective tissue remodeling using infrared photoacoustic spectra",

abstract = "Premature cervical remodeling is a critical precursor of spontaneous preterm birth, and the remodeling process is characterized by an increase in tissue hydration. Nevertheless, current clinical measurements of cervical remodeling are subjective and detect only late events, such as cervical effacement and dilation. Here, we present a photoacoustic endoscope that can quantify tissue hydration by measuring near-infrared cervical spectra. We quantify the water contents of tissue-mimicking hydrogel phantoms as an analog of cervical connective tissue. Applying this method to pregnant women in vivo, we observed an increase in the water content of the cervix throughout pregnancy. The application of this technique in maternal healthcare may advance our understanding of cervical remodeling and provide a sensitive method for predicting preterm birth.",

keywords = "cervical examination, photoacoustic endoscopy, spectroscopy, tissue hydration",

author = "Yuan Qu and Peng Hu and Junhui Shi and Konstantin Maslov and Peinan Zhao and Chiye Li and Jun Ma and Alejandro Garcia-Uribe and Karen Meyers and Emily Diveley and Stephanie Pizzella and Lisa Muench and Nina Punyamurthy and Naomi Goldstein and Oji Onwumere and Mariana Alisio and Kaytelyn Meyenburg and Jennifer Maynard and Kristi Helm and Emma Altieri and Janessia Slaughter and Sabrina Barber and Tracy Burger and Christine Kramer and Jessica Chubiz and Monica Anderson and Ronald McCarthy and England, {Sarah K.} and Macones, {George A.} and Stout, {Molly J.} and Methodius Tuuli and Wang, {Lihong V.}",

note = "Publisher Copyright: {\textcopyright} The Authors.",

year = "2018",

month = dec,

day = "1",

doi = "10.1117/1.JBO.23.12.121621",

language = "English",

volume = "23",

journal = "Journal of biomedical optics",

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Qu, Y, Hu, P, Shi, J, Maslov, K, Zhao, P, Li, C, Ma, J, Garcia-Uribe, A, Meyers, K, Diveley, E, Pizzella, S, Muench, L, Punyamurthy, N, Goldstein, N, Onwumere, O, Alisio, M, Meyenburg, K, Maynard, J, Helm, K, Altieri, E, Slaughter, J, Barber, S, Burger, T, Kramer, C, Chubiz, J, Anderson, M, McCarthy, R, England, SK, Macones, GA, Stout, MJ, Tuuli, M & Wang, LV 2018, 'In vivo characterization of connective tissue remodeling using infrared photoacoustic spectra', Journal of biomedical optics, vol. 23, no. 12, 121621. https://doi.org/10.1117/1.JBO.23.12.121621

TY - JOUR

T1 - In vivo characterization of connective tissue remodeling using infrared photoacoustic spectra

AU - Qu, Yuan

AU - Hu, Peng

AU - Shi, Junhui

AU - Maslov, Konstantin

AU - Zhao, Peinan

AU - Li, Chiye

AU - Ma, Jun

AU - Garcia-Uribe, Alejandro

AU - Meyers, Karen

AU - Diveley, Emily

AU - Pizzella, Stephanie

AU - Muench, Lisa

AU - Punyamurthy, Nina

AU - Goldstein, Naomi

AU - Onwumere, Oji

AU - Alisio, Mariana

AU - Meyenburg, Kaytelyn

AU - Maynard, Jennifer

AU - Helm, Kristi

AU - Altieri, Emma

AU - Slaughter, Janessia

AU - Barber, Sabrina

AU - Burger, Tracy

AU - Kramer, Christine

AU - Chubiz, Jessica

AU - Anderson, Monica

AU - McCarthy, Ronald

AU - England, Sarah K.

AU - Macones, George A.

AU - Stout, Molly J.

AU - Tuuli, Methodius

AU - Wang, Lihong V.

PY - 2018/12/1

Y1 - 2018/12/1

N2 - Premature cervical remodeling is a critical precursor of spontaneous preterm birth, and the remodeling process is characterized by an increase in tissue hydration. Nevertheless, current clinical measurements of cervical remodeling are subjective and detect only late events, such as cervical effacement and dilation. Here, we present a photoacoustic endoscope that can quantify tissue hydration by measuring near-infrared cervical spectra. We quantify the water contents of tissue-mimicking hydrogel phantoms as an analog of cervical connective tissue. Applying this method to pregnant women in vivo, we observed an increase in the water content of the cervix throughout pregnancy. The application of this technique in maternal healthcare may advance our understanding of cervical remodeling and provide a sensitive method for predicting preterm birth.

AB - Premature cervical remodeling is a critical precursor of spontaneous preterm birth, and the remodeling process is characterized by an increase in tissue hydration. Nevertheless, current clinical measurements of cervical remodeling are subjective and detect only late events, such as cervical effacement and dilation. Here, we present a photoacoustic endoscope that can quantify tissue hydration by measuring near-infrared cervical spectra. We quantify the water contents of tissue-mimicking hydrogel phantoms as an analog of cervical connective tissue. Applying this method to pregnant women in vivo, we observed an increase in the water content of the cervix throughout pregnancy. The application of this technique in maternal healthcare may advance our understanding of cervical remodeling and provide a sensitive method for predicting preterm birth.

KW - cervical examination

KW - photoacoustic endoscopy

KW - spectroscopy

KW - tissue hydration

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U2 - 10.1117/1.JBO.23.12.121621

DO - 10.1117/1.JBO.23.12.121621

M3 - Article

C2 - 30520275

AN - SCOPUS:85058278212

SN - 1083-3668

VL - 23

JO - Journal of biomedical optics

JF - Journal of biomedical optics

IS - 12

M1 - 121621

ER -

In vivo characterization of connective tissue remodeling using infrared photoacoustic spectra

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Keywords

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