TY - JOUR
T1 - In vivo Assessment of Supra-Cervical Fetal Membrane by MRI 3D CISS
T2 - A Preliminary Study
AU - Qi, Wenxu
AU - Zhao, Peinan
AU - Wang, Wei
AU - Sun, Zhexian
AU - Ma, Xiao
AU - Wang, Hui
AU - Wu, Wenjie
AU - Wen, Zichao
AU - Kisrieva-Ware, Zulfia
AU - Woodard, Pamela K.
AU - Wang, Qing
AU - McKinstry, Robert C.
AU - Wang, Yong
N1 - Publisher Copyright:
© Copyright © 2020 Qi, Zhao, Wang, Sun, Ma, Wang, Wu, Wen, Kisrieva-Ware, Woodard, Wang, McKinstry and Wang.
PY - 2020/6/25
Y1 - 2020/6/25
N2 - In approximately 8% of term births and 33% of pre-term births, the fetal membrane (FM) ruptures before delivery. In vitro studies of FMs after delivery have suggested the series of events leading to rupture, but no in vivo studies have confirmed this model. In this study, we used a three-dimensional constructive interference in steady state (3D-CISS) sequence to examine the FM at the cervical internal os zone during pregnancy; 18 pregnant women with one to three longitudinal MRI scans were included in this study. In 14 women, the FM appeared normal and completely intact. In four women, we noted several FM abnormalities including cervical funneling, chorioamniotic separation, and chorion rupture. Our data support the in vitro model that the FM ruptures according to a sequence starting with the stretch of chorion and amnion, then the separation of amnion from chorion, next the rupture of chorion, and finally the rupture of amnion ruptures. These findings hold great promise to help to develop an in vivo magnetic resonance imaging marker that improves examination of the FMs.
AB - In approximately 8% of term births and 33% of pre-term births, the fetal membrane (FM) ruptures before delivery. In vitro studies of FMs after delivery have suggested the series of events leading to rupture, but no in vivo studies have confirmed this model. In this study, we used a three-dimensional constructive interference in steady state (3D-CISS) sequence to examine the FM at the cervical internal os zone during pregnancy; 18 pregnant women with one to three longitudinal MRI scans were included in this study. In 14 women, the FM appeared normal and completely intact. In four women, we noted several FM abnormalities including cervical funneling, chorioamniotic separation, and chorion rupture. Our data support the in vitro model that the FM ruptures according to a sequence starting with the stretch of chorion and amnion, then the separation of amnion from chorion, next the rupture of chorion, and finally the rupture of amnion ruptures. These findings hold great promise to help to develop an in vivo magnetic resonance imaging marker that improves examination of the FMs.
KW - amnion
KW - chorion
KW - fetal membrane
KW - magnetic resonance imaging
KW - premature rupture of membranes
KW - preterm birth
KW - preterm premature rupture of membranes
UR - http://www.scopus.com/inward/record.url?scp=85087739113&partnerID=8YFLogxK
U2 - 10.3389/fphys.2020.00639
DO - 10.3389/fphys.2020.00639
M3 - Article
C2 - 32670086
AN - SCOPUS:85087739113
SN - 1664-042X
VL - 11
JO - Frontiers in Physiology
JF - Frontiers in Physiology
M1 - 639
ER -