In vitro evaluation of MR hypointensity in Aspergillus colonies

D. W. Fellows, V. D. King, T. Conturo, R. N. Bryan, W. G. Merz, S. J. Zinreich

Research output: Contribution to journalArticle

26 Scopus citations

Abstract

PURPOSE: To demonstrate that paramagnetic elements in fungal colonies can cause hypointensity in MR images. METHODS: Aspergillus fumigatus grown in vitro was imaged with CT and MR at the time of initial inoculation and 5 days later. CT and MR images, T2 values, scanning electron microscopy, energy- dispersive analysis, and furnace atomic absorption spectrometry were performed. RESULTS: After 5 days of growth, MR images of A fumigatus revealed curvilinear hypointensities on T2-weighted images corresponding to the fungal growth. Gradient-echo images revealed two distinct components of hypointensity with different calculated T2 values. Phase-angle-difference images revealed a phase shift characteristic of magnetic-susceptibility paramagnetic effects, which corresponded to the hypointense regions on gradient-echo images. Energy-dispersive analysis and furnace atomic absorption spectrometry confirmed the presence of paramagnetic elements. CONCLUSION: It was shown that in vitro A fumigatus concentrates metal elements contained within the nutrient broth. These focal collections of calculated T2 values are caused at least partly by magnetic susceptibility effects.

Original languageEnglish
Pages (from-to)1139-1144
Number of pages6
JournalAmerican Journal of Neuroradiology
Volume15
Issue number6
StatePublished - Jan 1 1994
Externally publishedYes

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    Fellows, D. W., King, V. D., Conturo, T., Bryan, R. N., Merz, W. G., & Zinreich, S. J. (1994). In vitro evaluation of MR hypointensity in Aspergillus colonies. American Journal of Neuroradiology, 15(6), 1139-1144.