In vitro differentiation potential of mesenchymal stem cells

Jeffrey M. Gimble; Farshid Guilak; Mark E. Nuttall; Solomon Sathishkumar; Martin Vidal; Bruce A. Bunnell

doi:10.1159/000124281

In vitro differentiation potential of mesenchymal stem cells

Jeffrey M. Gimble, Farshid Guilak, Mark E. Nuttall, Solomon Sathishkumar, Martin Vidal, Bruce A. Bunnell

Research output: Contribution to journal › Review article › peer-review

106 Scopus citations

Abstract

Mesenchymal stem cells (MSCs) represent a class of multipotent progenitor cells that have been isolated from multiple tissue sites. Of these, adipose tissue and bone marrow offer advantages in terms of access, abundance, and the extent of their documentation in the literature. This review focuses on the in vitro differentiation capability of cells derived from adult human tissue. Multiple, independent studies have demonstrated that MSCs can commit to mesodermal (adipocyte, chondrocyte, hematopoietic support, myocyte, osteoblast, tenocyte), ectodermal (epithelial, glial, neural), and endodermal (hepatocyte, islet cell) lineages. The limitations and promises of these studies in the context of tissue engineering are discussed.

Original language	English
Pages (from-to)	228-238
Number of pages	11
Journal	Transfusion Medicine and Hemotherapy
Volume	35
Issue number	3
DOIs	https://doi.org/10.1159/000124281
State	Published - Jun 2008

Keywords

Adipose-derived stem cells
Differentiation
Mesenchymal stem cells

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10.1159/000124281

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title = "In vitro differentiation potential of mesenchymal stem cells",

abstract = "Mesenchymal stem cells (MSCs) represent a class of multipotent progenitor cells that have been isolated from multiple tissue sites. Of these, adipose tissue and bone marrow offer advantages in terms of access, abundance, and the extent of their documentation in the literature. This review focuses on the in vitro differentiation capability of cells derived from adult human tissue. Multiple, independent studies have demonstrated that MSCs can commit to mesodermal (adipocyte, chondrocyte, hematopoietic support, myocyte, osteoblast, tenocyte), ectodermal (epithelial, glial, neural), and endodermal (hepatocyte, islet cell) lineages. The limitations and promises of these studies in the context of tissue engineering are discussed.",

keywords = "Adipose-derived stem cells, Differentiation, Mesenchymal stem cells",

author = "Gimble, {Jeffrey M.} and Farshid Guilak and Nuttall, {Mark E.} and Solomon Sathishkumar and Martin Vidal and Bunnell, {Bruce A.}",

year = "2008",

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T1 - In vitro differentiation potential of mesenchymal stem cells

AU - Gimble, Jeffrey M.

AU - Guilak, Farshid

AU - Nuttall, Mark E.

AU - Sathishkumar, Solomon

AU - Vidal, Martin

AU - Bunnell, Bruce A.

PY - 2008/6

Y1 - 2008/6

N2 - Mesenchymal stem cells (MSCs) represent a class of multipotent progenitor cells that have been isolated from multiple tissue sites. Of these, adipose tissue and bone marrow offer advantages in terms of access, abundance, and the extent of their documentation in the literature. This review focuses on the in vitro differentiation capability of cells derived from adult human tissue. Multiple, independent studies have demonstrated that MSCs can commit to mesodermal (adipocyte, chondrocyte, hematopoietic support, myocyte, osteoblast, tenocyte), ectodermal (epithelial, glial, neural), and endodermal (hepatocyte, islet cell) lineages. The limitations and promises of these studies in the context of tissue engineering are discussed.

AB - Mesenchymal stem cells (MSCs) represent a class of multipotent progenitor cells that have been isolated from multiple tissue sites. Of these, adipose tissue and bone marrow offer advantages in terms of access, abundance, and the extent of their documentation in the literature. This review focuses on the in vitro differentiation capability of cells derived from adult human tissue. Multiple, independent studies have demonstrated that MSCs can commit to mesodermal (adipocyte, chondrocyte, hematopoietic support, myocyte, osteoblast, tenocyte), ectodermal (epithelial, glial, neural), and endodermal (hepatocyte, islet cell) lineages. The limitations and promises of these studies in the context of tissue engineering are discussed.

KW - Adipose-derived stem cells

KW - Differentiation

KW - Mesenchymal stem cells

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DO - 10.1159/000124281

M3 - Review article

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AN - SCOPUS:49649116140

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VL - 35

SP - 228

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JO - Transfusion Medicine and Hemotherapy

JF - Transfusion Medicine and Hemotherapy

IS - 3

ER -

In vitro differentiation potential of mesenchymal stem cells

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Keywords

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