In vitro cultivation of the exoerythrocytic stage of Plasmodium berghei in a hepatoma cell line

M. R. Hollingdale; P. Leland; A. L. Schwartz

doi:10.4269/ajtmh.1983.32.682

In vitro cultivation of the exoerythrocytic stage of Plasmodium berghei in a hepatoma cell line

M. R. Hollingdale, P. Leland, A. L. Schwartz

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Abstract

When inoculated with sporozoites of Plasmodium berghei, a line of hepatoma cells (HepG2-A16) derived from human liver supports the complete asexual developmental cycle of exoerythrocytic stage. Parasites were shown to resemble parasites in vivo in hepatocytes. Subinoculation of merozoites into mice induced a red blood cell infection.

Original language	English
Pages (from-to)	682-684
Number of pages	3
Journal	American Journal of Tropical Medicine and Hygiene
Volume	32
Issue number	4
DOIs	https://doi.org/10.4269/ajtmh.1983.32.682
State	Published - 1983

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10.4269/ajtmh.1983.32.682

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title = "In vitro cultivation of the exoerythrocytic stage of Plasmodium berghei in a hepatoma cell line",

abstract = "When inoculated with sporozoites of Plasmodium berghei, a line of hepatoma cells (HepG2-A16) derived from human liver supports the complete asexual developmental cycle of exoerythrocytic stage. Parasites were shown to resemble parasites in vivo in hepatocytes. Subinoculation of merozoites into mice induced a red blood cell infection.",

author = "Hollingdale, {M. R.} and P. Leland and Schwartz, {A. L.}",

year = "1983",

doi = "10.4269/ajtmh.1983.32.682",

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pages = "682--684",

journal = "American Journal of Tropical Medicine and Hygiene",

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AU - Hollingdale, M. R.

AU - Leland, P.

AU - Schwartz, A. L.

PY - 1983

Y1 - 1983

N2 - When inoculated with sporozoites of Plasmodium berghei, a line of hepatoma cells (HepG2-A16) derived from human liver supports the complete asexual developmental cycle of exoerythrocytic stage. Parasites were shown to resemble parasites in vivo in hepatocytes. Subinoculation of merozoites into mice induced a red blood cell infection.

AB - When inoculated with sporozoites of Plasmodium berghei, a line of hepatoma cells (HepG2-A16) derived from human liver supports the complete asexual developmental cycle of exoerythrocytic stage. Parasites were shown to resemble parasites in vivo in hepatocytes. Subinoculation of merozoites into mice induced a red blood cell infection.

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U2 - 10.4269/ajtmh.1983.32.682

DO - 10.4269/ajtmh.1983.32.682

M3 - Article

C2 - 6349397

AN - SCOPUS:0020516751

VL - 32

SP - 682

EP - 684

JO - American Journal of Tropical Medicine and Hygiene

JF - American Journal of Tropical Medicine and Hygiene

SN - 0002-9637

IS - 4

ER -

In vitro cultivation of the exoerythrocytic stage of Plasmodium berghei in a hepatoma cell line

Abstract

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