In vitro cultivation of the exoerythrocytic stage of Plasmodium berghei in a hepatoma cell line

M. R. Hollingdale, P. Leland, A. L. Schwartz

Research output: Contribution to journalArticle

69 Scopus citations

Abstract

When inoculated with sporozoites of Plasmodium berghei, a line of hepatoma cells (HepG2-A16) derived from human liver supports the complete asexual developmental cycle of exoerythrocytic stage. Parasites were shown to resemble parasites in vivo in hepatocytes. Subinoculation of merozoites into mice induced a red blood cell infection.

Original languageEnglish
Pages (from-to)682-684
Number of pages3
JournalAmerican Journal of Tropical Medicine and Hygiene
Volume32
Issue number4
DOIs
StatePublished - Jan 1 1983
Externally publishedYes

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