In situ hybridizatrion of nerve growth factor mRNA in the mouse submandibular gland

E. C. Salido; P. H. Yen; L. J. Shapiro; D. A. Fisher; L. Barajas

In situ hybridizatrion of nerve growth factor mRNA in the mouse submandibular gland

E. C. Salido, P. H. Yen, L. J. Shapiro, D. A. Fisher, L. Barajas

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Abstract

We studied the presence of β-nerve growth factor (NGF) mRNA in the submandibular gland of the mouse by in situ hybridization using ³⁵S-labeled prepro-β-NGF antisense RNA. Female and male mice were studied at different stages of postnatal development, ranging from 3 to 12 weeks. Although NGF mRNA was detectable in the granular convoluted tubules of the submandibular gland in all the age and sex groups studied, the abundance of the signal dramatically increased after 5 weeks during the development of the submandibular gland. In addition, a conspicuous sexual dimorphism became increasingly apparent in the 6-, 7-, 10-, and 12-week-old animals, due to the remarkable development of the granular convoluted tubules in the adult male mouse, that expressed abundant NGF mRNA.

Original language	English
Pages (from-to)	625-630
Number of pages	6
Journal	Laboratory Investigation
Volume	59
Issue number	5
State	Published - 1988

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title = "In situ hybridizatrion of nerve growth factor mRNA in the mouse submandibular gland",

abstract = "We studied the presence of β-nerve growth factor (NGF) mRNA in the submandibular gland of the mouse by in situ hybridization using 35S-labeled prepro-β-NGF antisense RNA. Female and male mice were studied at different stages of postnatal development, ranging from 3 to 12 weeks. Although NGF mRNA was detectable in the granular convoluted tubules of the submandibular gland in all the age and sex groups studied, the abundance of the signal dramatically increased after 5 weeks during the development of the submandibular gland. In addition, a conspicuous sexual dimorphism became increasingly apparent in the 6-, 7-, 10-, and 12-week-old animals, due to the remarkable development of the granular convoluted tubules in the adult male mouse, that expressed abundant NGF mRNA.",

author = "Salido, {E. C.} and Yen, {P. H.} and Shapiro, {L. J.} and Fisher, {D. A.} and L. Barajas",

year = "1988",

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T1 - In situ hybridizatrion of nerve growth factor mRNA in the mouse submandibular gland

AU - Salido, E. C.

AU - Yen, P. H.

AU - Shapiro, L. J.

AU - Fisher, D. A.

AU - Barajas, L.

PY - 1988

Y1 - 1988

N2 - We studied the presence of β-nerve growth factor (NGF) mRNA in the submandibular gland of the mouse by in situ hybridization using 35S-labeled prepro-β-NGF antisense RNA. Female and male mice were studied at different stages of postnatal development, ranging from 3 to 12 weeks. Although NGF mRNA was detectable in the granular convoluted tubules of the submandibular gland in all the age and sex groups studied, the abundance of the signal dramatically increased after 5 weeks during the development of the submandibular gland. In addition, a conspicuous sexual dimorphism became increasingly apparent in the 6-, 7-, 10-, and 12-week-old animals, due to the remarkable development of the granular convoluted tubules in the adult male mouse, that expressed abundant NGF mRNA.

AB - We studied the presence of β-nerve growth factor (NGF) mRNA in the submandibular gland of the mouse by in situ hybridization using 35S-labeled prepro-β-NGF antisense RNA. Female and male mice were studied at different stages of postnatal development, ranging from 3 to 12 weeks. Although NGF mRNA was detectable in the granular convoluted tubules of the submandibular gland in all the age and sex groups studied, the abundance of the signal dramatically increased after 5 weeks during the development of the submandibular gland. In addition, a conspicuous sexual dimorphism became increasingly apparent in the 6-, 7-, 10-, and 12-week-old animals, due to the remarkable development of the granular convoluted tubules in the adult male mouse, that expressed abundant NGF mRNA.

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M3 - Article

C2 - 2460695

AN - SCOPUS:0024166631

SN - 0023-6837

VL - 59

SP - 625

EP - 630

JO - Laboratory Investigation

JF - Laboratory Investigation

IS - 5

ER -

In situ hybridizatrion of nerve growth factor mRNA in the mouse submandibular gland

Abstract

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