In search of new therapeutic targets and strategies for heart failure: Recent advances in basic science

Ajay M. Shah, Douglas L. Mann

Research output: Contribution to journalReview articlepeer-review

199 Scopus citations

Abstract

Chronic heart failure continues to impose a substantial health-care burden, despite recent treatment advances. The key pathophysiological process that ultimately leads to chronic heart failure is cardiac remodelling in response to chronic disease stresses. Here, we review recent advances in our understanding of molecular and cellular mechanisms that play a part in the complex remodelling process, with a focus on key molecules and pathways that might be suitable targets for therapeutic manipulation. Such pathways include those that regulate cardiac myocyte hypertrophy, calcium homoeostasis, energetics, and cell survival, and processes that take place outside the cardiac myocyte - eg, in the myocardial vasculature and extracellular matrix. We also discuss major gaps in our current understanding, take a critical look at conventional approaches to target discovery that have been used to date, and consider new investigational avenues that might accelerate clinically relevant discovery.

Original languageEnglish
Pages (from-to)704-712
Number of pages9
JournalThe Lancet
Volume378
Issue number9792
DOIs
StatePublished - Jan 1 2011

Fingerprint Dive into the research topics of 'In search of new therapeutic targets and strategies for heart failure: Recent advances in basic science'. Together they form a unique fingerprint.

Cite this