Improvement in sexual functioning in patients with type 2 diabetes and depression treated with bupropion

Gregory S. Sayuk; Britt M. Gott; Billy D. Nix; Patrick J. Lustman

doi:10.2337/dc10-1714

Improvement in sexual functioning in patients with type 2 diabetes and depression treated with bupropion

Gregory S. Sayuk, Britt M. Gott, Billy D. Nix, Patrick J. Lustman

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15 Scopus citations

Abstract

OBJECTIVE - Major depressive disorder (MDD) and type 2 diabetes have independent adverse effects on sexual functioning (SF). Bupropion (BU) reportedly has few sexual side effects, but its use in diabetes has not been studied. RESEARCH DESIGN ANDMETHODS - This article reports a planned secondary analysis of SF in 90 patients with type 2 diabetes treated with BU for MDD. RESULTS - At baseline, 71.1%of patients had insufficient SF.Mean Sexual Energy Scale (SES) scores improved during treatment (P<0.0001), as did the percentage with sufficient SF (30.6 vs. 68.1%, P = 0.001). Patients with persistent hyperglycemia had higher rates of sexual dysfunction; however, SES improvement was evident in some with persistent depression or hyperglycemia (18.2% and 25.9%, respectively). CONCLUSIONS - Insufficient SF is prevalent and may be suspected in patients with MDD and type 2 diabetes. BU treatment of MDD had few sexual side effects and was associated with significant improvements in SF.

Original language	English
Pages (from-to)	332-334
Number of pages	3
Journal	Diabetes care
Volume	34
Issue number	2
DOIs	https://doi.org/10.2337/dc10-1714
State	Published - Feb 2011

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title = "Improvement in sexual functioning in patients with type 2 diabetes and depression treated with bupropion",

abstract = "OBJECTIVE - Major depressive disorder (MDD) and type 2 diabetes have independent adverse effects on sexual functioning (SF). Bupropion (BU) reportedly has few sexual side effects, but its use in diabetes has not been studied. RESEARCH DESIGN ANDMETHODS - This article reports a planned secondary analysis of SF in 90 patients with type 2 diabetes treated with BU for MDD. RESULTS - At baseline, 71.1%of patients had insufficient SF.Mean Sexual Energy Scale (SES) scores improved during treatment (P<0.0001), as did the percentage with sufficient SF (30.6 vs. 68.1%, P = 0.001). Patients with persistent hyperglycemia had higher rates of sexual dysfunction; however, SES improvement was evident in some with persistent depression or hyperglycemia (18.2% and 25.9%, respectively). CONCLUSIONS - Insufficient SF is prevalent and may be suspected in patients with MDD and type 2 diabetes. BU treatment of MDD had few sexual side effects and was associated with significant improvements in SF.",

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T1 - Improvement in sexual functioning in patients with type 2 diabetes and depression treated with bupropion

AU - Sayuk, Gregory S.

AU - Gott, Britt M.

AU - Nix, Billy D.

AU - Lustman, Patrick J.

PY - 2011/2

Y1 - 2011/2

N2 - OBJECTIVE - Major depressive disorder (MDD) and type 2 diabetes have independent adverse effects on sexual functioning (SF). Bupropion (BU) reportedly has few sexual side effects, but its use in diabetes has not been studied. RESEARCH DESIGN ANDMETHODS - This article reports a planned secondary analysis of SF in 90 patients with type 2 diabetes treated with BU for MDD. RESULTS - At baseline, 71.1%of patients had insufficient SF.Mean Sexual Energy Scale (SES) scores improved during treatment (P<0.0001), as did the percentage with sufficient SF (30.6 vs. 68.1%, P = 0.001). Patients with persistent hyperglycemia had higher rates of sexual dysfunction; however, SES improvement was evident in some with persistent depression or hyperglycemia (18.2% and 25.9%, respectively). CONCLUSIONS - Insufficient SF is prevalent and may be suspected in patients with MDD and type 2 diabetes. BU treatment of MDD had few sexual side effects and was associated with significant improvements in SF.

AB - OBJECTIVE - Major depressive disorder (MDD) and type 2 diabetes have independent adverse effects on sexual functioning (SF). Bupropion (BU) reportedly has few sexual side effects, but its use in diabetes has not been studied. RESEARCH DESIGN ANDMETHODS - This article reports a planned secondary analysis of SF in 90 patients with type 2 diabetes treated with BU for MDD. RESULTS - At baseline, 71.1%of patients had insufficient SF.Mean Sexual Energy Scale (SES) scores improved during treatment (P<0.0001), as did the percentage with sufficient SF (30.6 vs. 68.1%, P = 0.001). Patients with persistent hyperglycemia had higher rates of sexual dysfunction; however, SES improvement was evident in some with persistent depression or hyperglycemia (18.2% and 25.9%, respectively). CONCLUSIONS - Insufficient SF is prevalent and may be suspected in patients with MDD and type 2 diabetes. BU treatment of MDD had few sexual side effects and was associated with significant improvements in SF.

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Improvement in sexual functioning in patients with type 2 diabetes and depression treated with bupropion

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