Improved Synthesis of Chiral 1,4,7-Triazacyclononane Derivatives and Their Application in Ni-Catalyzed Csp³−Csp³ Kumada Cross-Coupling

Keyphrases

• Alkyl 100%
• 1,4,7-triazacyclononane 100%
• Ni-catalyzed 100%
• Kumada Coupling 100%
• Improved Synthesis 100%
• Cross-coupling Reaction 60%
• Sterically Hindered 40%
• Chloride Complexes 40%
• N-substituent 40%
• Dichlorides 40%
• Methyl 20%
• Alkyl Substituent 20%
• Dimethyl 20%
• Tris 20%
• Catalytic Activity 20%
• Complex Change 20%
• Cyclization Reaction 20%
• Chloro 20%
• Tert-butyl 20%
• Ni(II) Complex 20%
• Dinuclear 20%
• Nickel Complex 20%
• NiCl2 20%
• New Synthetic Method 20%
• High Enantioselectivity 20%
• Enantioconvergent 20%
• Dinickel Complexes 20%
• Coordination Geometry 20%
• Steric Bulk 20%
• Enantioenrichment 20%
• Chiral N 20%
• Rotational Isomer 20%
• Chiral Complexes 20%

Chemistry

• Cross-Coupling Reaction 100%
• Kumada Cross-Coupling 100%
• Cyclization Reaction 33%
• Enantioselectivity 33%
• Tris 33%
• Catalyst Activity 33%