TY - JOUR
T1 - Improved signal processing to detect cancer by ultrasonic molecular imaging of targeted nanoparticles
AU - Hughes, Michael
AU - Marsh, Jon
AU - Lanza, Gregory
AU - Wickline, Samuel
AU - McCarthy, John
AU - Wickerhauser, Victor
AU - Maurizi, Brian
AU - Wallace, Kirk
N1 - Funding Information:
This study was funded by NIH EB-002168, NIH HL-042950, HL-087847-02, and CO-27031 and NSF DMS 0966845. The research was carried out at the Washington University Department of Mathematics and the School of Medicine.
PY - 2011/6
Y1 - 2011/6
N2 - In several investigations of molecular imaging of angiogenic neovasculature using a targeted contrast agent, Renyi entropy I f (r) and a limiting form of Renyi entropy (I f,∞ ) exhibited significantly more sensitivity to subtle changes in scattering architecture than energy-based methods. Many of these studies required the fitting of a cubic spline to backscattered waveforms prior to calculation of entropy either I f (r) or I f,∞. In this study, it is shown that the robustness of I f,∞ may be improved by using a smoothing spline. Results are presented showing the impact of different smoothing parameters. In addition, if smoothing is preceded by low-pass filtering of the waveforms, further improvements may be obtained.
AB - In several investigations of molecular imaging of angiogenic neovasculature using a targeted contrast agent, Renyi entropy I f (r) and a limiting form of Renyi entropy (I f,∞ ) exhibited significantly more sensitivity to subtle changes in scattering architecture than energy-based methods. Many of these studies required the fitting of a cubic spline to backscattered waveforms prior to calculation of entropy either I f (r) or I f,∞. In this study, it is shown that the robustness of I f,∞ may be improved by using a smoothing spline. Results are presented showing the impact of different smoothing parameters. In addition, if smoothing is preceded by low-pass filtering of the waveforms, further improvements may be obtained.
UR - https://www.scopus.com/pages/publications/79959478635
U2 - 10.1121/1.3578459
DO - 10.1121/1.3578459
M3 - Article
C2 - 21682399
AN - SCOPUS:79959478635
SN - 0001-4966
VL - 129
SP - 3756
EP - 3767
JO - Journal of the Acoustical Society of America
JF - Journal of the Acoustical Society of America
IS - 6
ER -