Abstract
The relaxivity and transmetallation of two lipophilic paramagnetic chelates incorporated onto perfluorocarbon nanoparticles, i.e., gadolinium-methoxy- tetraazacyclododecane-tetraacetic acid phosphatidylethanolamine (Gd-MeO-DOTA-PE) and gadolinium-methoxy-tetraazacyclododecane-tetraacetic acid triglycine phosphatidylethanolamine (Gd-MeO-DOTA-triglycine-PE (Gd-MeO-DOTA-triglycine-PE)) , were compared to a prototypic gadolinium-diethylene-triamine-pentaacetic acid bis-oleate (Gd-DTPA-BOA) paramagnetic formulation. Nanoparticles with MeO-DOTA-based chelates demonstrated higher relaxivity (40% higher for Gd-MeO-DOTA-PE and 55% higher for Gd-MeO-DOTA-triglycine-PE) and less transmetallation than the original Gd-DTPA-BOA-based agent.
Original language | English |
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Pages (from-to) | 540-545 |
Number of pages | 6 |
Journal | Journal of Magnetism and Magnetic Materials |
Volume | 293 |
Issue number | 1 |
DOIs | |
State | Published - May 2005 |
Keywords
- Chelator
- Contrast agent
- DOTA
- DTPA
- Gadolinium
- Magnetic resonance imaging (MRI)
- Nanoparticles
- Perfluorocarbon
- Relaxivity
- Transmetallation