Improved paramagnetic chelate for molecular imaging with MRI

Patrick Winter, Phillip Athey, Garry Kiefer, Gyongyi Gulyas, Keith Frank, Ralph Fuhrhop, David Robertson, Samuel Wickline, Gregory Lanza

Research output: Contribution to journalArticlepeer-review

39 Scopus citations

Abstract

The relaxivity and transmetallation of two lipophilic paramagnetic chelates incorporated onto perfluorocarbon nanoparticles, i.e., gadolinium-methoxy- tetraazacyclododecane-tetraacetic acid phosphatidylethanolamine (Gd-MeO-DOTA-PE) and gadolinium-methoxy-tetraazacyclododecane-tetraacetic acid triglycine phosphatidylethanolamine (Gd-MeO-DOTA-triglycine-PE (Gd-MeO-DOTA-triglycine-PE)) , were compared to a prototypic gadolinium-diethylene-triamine-pentaacetic acid bis-oleate (Gd-DTPA-BOA) paramagnetic formulation. Nanoparticles with MeO-DOTA-based chelates demonstrated higher relaxivity (40% higher for Gd-MeO-DOTA-PE and 55% higher for Gd-MeO-DOTA-triglycine-PE) and less transmetallation than the original Gd-DTPA-BOA-based agent.

Original languageEnglish
Pages (from-to)540-545
Number of pages6
JournalJournal of Magnetism and Magnetic Materials
Volume293
Issue number1
DOIs
StatePublished - May 2005

Keywords

  • Chelator
  • Contrast agent
  • DOTA
  • DTPA
  • Gadolinium
  • Magnetic resonance imaging (MRI)
  • Nanoparticles
  • Perfluorocarbon
  • Relaxivity
  • Transmetallation

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