Improved lung preservation with dextran 40 is not mediated by a superoxide radical scavenging mechanism

S. H. Keshavjee, D. I. McRitchie, T. Vittorini, O. D. Rotstein, A. S. Slutsky, G. A. Patterson

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Improved lung preservation with a low-potassium dextran-containing solution has been previously demonstrated. In a subsequent study, it was shown that dextran 40 contributes significantly to this improved preservation. In the current in vitro study, human neutrophils suspended in lung preservation solutions (low potassium with dextran and low potassium without dextran) were stimulated to produce superoxide radicals. The presence of dextran in the solution did not significantly alter the amount of superoxide measured in the assay (low potassium with dextran, 4.149 ± 0.144 nmol/106 cells/20 min; low potassium without dextran, 3.896 ± 0.215; p > 0.2). This suggests that dextran 40 did not appreciably scavenge superoxide radicals, nor did it alter the production of superoxide radicals by stimulated neutrophils. Thus the significantly improved lung preservation seen with the use of dextran 40 is probably not mediated by a superoxide radical scavenging process.

Original languageEnglish
Pages (from-to)326-328
Number of pages3
JournalJournal of Thoracic and Cardiovascular Surgery
Volume103
Issue number2
DOIs
StatePublished - Jan 1 1992

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