Improved Graft Function following Desensitization of Anti-AT1R and Autoantibodies in a Heart Transplant Recipient Negative for Donor-Specific Antibodies with Antibody-Mediated Rejection: A Case Report

Regina Jung; Kevin Ly; Michiko Taniguchi; Aileen Grace Arriola; Christopher Gravante; Derek Shinn; Leena Mathew; Eman Hamad; Steven Geier; Abdelhamid Liacini

doi:10.3390/ijms25042218

Improved Graft Function following Desensitization of Anti-AT₁R and Autoantibodies in a Heart Transplant Recipient Negative for Donor-Specific Antibodies with Antibody-Mediated Rejection: A Case Report

Regina Jung, Kevin Ly, Michiko Taniguchi, Aileen Grace Arriola, Christopher Gravante, Derek Shinn, Leena Mathew, Eman Hamad, Steven Geier, Abdelhamid Liacini

Division of Laboratory and Genomic Medicine

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

HLA donor-specific antibodies (DSAs) pre and post transplant increase the risk of antibody-mediated rejection (AMR) and lead to poor graft survival. Increasing data exist to support the involvement of non-HLA antibodies in triggering an immunological response. The development of non-HLA antibodies specific for AT₁R is associated with poor clinical outcomes in orthotopic heart transplant recipients. This case presents an investigation of non-HLA antibodies in a 56-year-old female heart transplant recipient diagnosed with AMR in the absence of DSAs.

Original language	English
Article number	2218
Journal	International journal of molecular sciences
Volume	25
Issue number	4
DOIs	https://doi.org/10.3390/ijms25042218
State	Published - Feb 2024

Keywords

ATR
antibody-mediated rejection
autoantibodies
orthotopic heart transplantation
rejection

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10.3390/ijms25042218

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Jung, R., Ly, K., Taniguchi, M., Arriola, A. G., Gravante, C., Shinn, D., Mathew, L., Hamad, E., Geier, S., & Liacini, A. (2024). Improved Graft Function following Desensitization of Anti-AT₁R and Autoantibodies in a Heart Transplant Recipient Negative for Donor-Specific Antibodies with Antibody-Mediated Rejection: A Case Report. International journal of molecular sciences, 25(4), Article 2218. https://doi.org/10.3390/ijms25042218

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title = "Improved Graft Function following Desensitization of Anti-AT1R and Autoantibodies in a Heart Transplant Recipient Negative for Donor-Specific Antibodies with Antibody-Mediated Rejection: A Case Report",

abstract = "HLA donor-specific antibodies (DSAs) pre and post transplant increase the risk of antibody-mediated rejection (AMR) and lead to poor graft survival. Increasing data exist to support the involvement of non-HLA antibodies in triggering an immunological response. The development of non-HLA antibodies specific for AT1R is associated with poor clinical outcomes in orthotopic heart transplant recipients. This case presents an investigation of non-HLA antibodies in a 56-year-old female heart transplant recipient diagnosed with AMR in the absence of DSAs.",

keywords = "ATR, antibody-mediated rejection, autoantibodies, orthotopic heart transplantation, rejection",

author = "Regina Jung and Kevin Ly and Michiko Taniguchi and Arriola, {Aileen Grace} and Christopher Gravante and Derek Shinn and Leena Mathew and Eman Hamad and Steven Geier and Abdelhamid Liacini",

note = "Publisher Copyright: {\textcopyright} 2024 by the authors.",

year = "2024",

month = feb,

doi = "10.3390/ijms25042218",

language = "English",

volume = "25",

journal = "International journal of molecular sciences",

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Jung, R, Ly, K, Taniguchi, M, Arriola, AG, Gravante, C, Shinn, D, Mathew, L, Hamad, E, Geier, S & Liacini, A 2024, 'Improved Graft Function following Desensitization of Anti-AT₁R and Autoantibodies in a Heart Transplant Recipient Negative for Donor-Specific Antibodies with Antibody-Mediated Rejection: A Case Report', International journal of molecular sciences, vol. 25, no. 4, 2218. https://doi.org/10.3390/ijms25042218

Improved Graft Function following Desensitization of Anti-AT₁R and Autoantibodies in a Heart Transplant Recipient Negative for Donor-Specific Antibodies with Antibody-Mediated Rejection: A Case Report. / Jung, Regina; Ly, Kevin; Taniguchi, Michiko et al.
In: International journal of molecular sciences, Vol. 25, No. 4, 2218, 02.2024.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Improved Graft Function following Desensitization of Anti-AT1R and Autoantibodies in a Heart Transplant Recipient Negative for Donor-Specific Antibodies with Antibody-Mediated Rejection

T2 - A Case Report

AU - Jung, Regina

AU - Ly, Kevin

AU - Taniguchi, Michiko

AU - Arriola, Aileen Grace

AU - Gravante, Christopher

AU - Shinn, Derek

AU - Mathew, Leena

AU - Hamad, Eman

AU - Geier, Steven

AU - Liacini, Abdelhamid

PY - 2024/2

Y1 - 2024/2

N2 - HLA donor-specific antibodies (DSAs) pre and post transplant increase the risk of antibody-mediated rejection (AMR) and lead to poor graft survival. Increasing data exist to support the involvement of non-HLA antibodies in triggering an immunological response. The development of non-HLA antibodies specific for AT1R is associated with poor clinical outcomes in orthotopic heart transplant recipients. This case presents an investigation of non-HLA antibodies in a 56-year-old female heart transplant recipient diagnosed with AMR in the absence of DSAs.

AB - HLA donor-specific antibodies (DSAs) pre and post transplant increase the risk of antibody-mediated rejection (AMR) and lead to poor graft survival. Increasing data exist to support the involvement of non-HLA antibodies in triggering an immunological response. The development of non-HLA antibodies specific for AT1R is associated with poor clinical outcomes in orthotopic heart transplant recipients. This case presents an investigation of non-HLA antibodies in a 56-year-old female heart transplant recipient diagnosed with AMR in the absence of DSAs.

KW - ATR

KW - antibody-mediated rejection

KW - autoantibodies

KW - orthotopic heart transplantation

KW - rejection

UR - http://www.scopus.com/inward/record.url?scp=85185958398&partnerID=8YFLogxK

U2 - 10.3390/ijms25042218

DO - 10.3390/ijms25042218

M3 - Article

C2 - 38396895

AN - SCOPUS:85185958398

SN - 1661-6596

VL - 25

JO - International journal of molecular sciences

JF - International journal of molecular sciences

IS - 4

M1 - 2218

ER -

Improved Graft Function following Desensitization of Anti-AT₁R and Autoantibodies in a Heart Transplant Recipient Negative for Donor-Specific Antibodies with Antibody-Mediated Rejection: A Case Report

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