Improved detection sensitivity of line-scanning optical coherence microscopy

Yu Chen, Shu Wei Huang, Chao Zhou, Benjamin Potsaid, James G. Fujimoto

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


Optical coherence microscopy (OCM) is a promising technology for high-resolution cellular-level imaging in human tissues. Line-scanning OCM is a new form of OCM that utilizes line-field illumination for parallel detection. In this study, we demonstrate improved detection sensitivity by using an achromatic design for line-field generation. This system operates at 830-nm wavelength with 82-nm bandwidth. The measured axial resolution is 3.9 μm in air (corresponding to ∼2.9 μm in tissue), and the transverse resolutions are 2.1 μm along the line-field illumination direction and 1.7 μm perpendicular to line illumination direction. The measured sensitivity is 98 dB with 25 line averages, resulting in an imaging speed of ∼2 frames/s (516 lines/s). Real-time, cellular-level imaging of scattering tissues is demonstrated using human-colon specimens.

Original languageEnglish
Article number5951723
Pages (from-to)1094-1099
Number of pages6
JournalIEEE Journal on Selected Topics in Quantum Electronics
Issue number3
StatePublished - 2012


  • Confocal microscopy
  • medical and biological imaging
  • optical coherence microscopy (OCM)
  • optical coherence tomography (OCT)


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