Rabbit alveolar macrophages at high cell concentrations are inefficiently radiolabeled by the usual lactoperoxidase-catalyzed iodination method. Soluble macromolecules secreted by macrophages were found to inhibit the radioiodination of macrophages and other cells. A modified procedure is described which minimizes the presence of such inihibitory material and thereby considerably improves the radioiodination efficiency for both alviolar macrophages and the macrophage-like P388D1 cell line.

Original languageEnglish
Pages (from-to)133-138
Number of pages6
JournalJournal of Immunological Methods
Issue number2
StatePublished - 1980


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