Improve myocardial T1 measurement in rats with a new regression model: application to myocardial infarction and beyond

Haosen Zhang, Qing Ye, Jie Zheng, Erik B. Schelbert, T. Kevin Hitchens, Chien Ho

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

PURPOSE: To improve myocardial and blood T1 measurements with a multi-variable T1 fitting model specifically modified for a segmented multi-shot FLASH sequence.

METHODS: The proposed method was first evaluated in a series of phantoms simulating realistic tissues, and then in healthy rats (n = 8) and rats with acute myocardial infarction (MI) induced by coronary artery ligation (n = 8).

RESULTS: By taking into account the saturation effect caused by sampling α-train pulses, and the longitudinal magnetization recovery between readouts, our model provided more accurate T1 estimate than the conventional three-parameter fit in phantoms under realistic gating procedures (error of -0.42 ± 1.73% versus -3.40 ± 1.46%, respectively, when using the measured inversion efficiency, β). The baseline myocardial T1 values in healthy rats was 1636.3 ± 23.4 ms at 7 Tesla. One day postligation, the T1 values in the remote and proximal myocardial areas were 1637.5 ± 62.6 ms and 1740.3 ± 70.5 ms, respectively. In rats with acute MI, regional differences in myocardial T1 values were observed both before and after the administration of gadolinium.

CONCLUSION: The proposed method has improved T1 estimate as validated in phantoms and could advance applications in rodents using quantitative myocardial T1 mapping.

Original languageEnglish
Pages (from-to)737-748
Number of pages12
JournalMagnetic resonance in medicine
Volume72
Issue number3
DOIs
StatePublished - Sep 1 2014
Externally publishedYes

Keywords

  • T1 regression model
  • acute myocardial infarction
  • myocardial and blood T1
  • rats
  • segmented multi-shot FLASH

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