Imprinted antibody responses against SARS-CoV-2 Omicron sublineages

Young Jun Park; Dora Pinto; Alexandra C. Walls; Zhuoming Liu; Anna De Marco; Fabio Benigni; Fabrizia Zatta; Chiara Silacci-Fregn; Jessica Bassi; Kaitlin R. Sprouse; Amin Addetia; John E. Bowen; Cameron Stewart; Martina Giurdanella; Christian Saliba; Barbara Guarino; Michael A. Schmid; Nicholas M. Franko; Jennifer K. Logue; Ha V. Dang; Kevin Hauser; Julia Di Iulio; William Rivera; Gretja Schnell; Anushka Rajesh; Jiayi Zhou; Nisar Farhat; Hannah Kaiser; Martin Montiel-Rui; Julia Noack; Florian A. Lempp; Javier Janer; Rana Abdelnabi; Piet Maes; Paolo Ferrari; Alessandro Ceschi; Olivier Giannini; Guilherme Dias De Melo; Lauriane Kergoat; Hervé Bourhy; Johan Neyts; Leah Soriaga; Lisa A. Purcell; Gyorgy Snell; Sean P.J. Whelan; Antonio Lanzavecchia; Herbert W. Virgin; Luca Piccoli; Helen Y. Chu; Matteo Samuele Pizzuto; Davide Corti; David Veesler

doi:10.1126/science.adc9127

Imprinted antibody responses against SARS-CoV-2 Omicron sublineages

Young Jun Park, Dora Pinto, Alexandra C. Walls, Zhuoming Liu, Anna De Marco, Fabio Benigni, Fabrizia Zatta, Chiara Silacci-Fregn, Jessica Bassi, Kaitlin R. Sprouse, Amin Addetia, John E. Bowen, Cameron Stewart, Martina Giurdanella, Christian Saliba, Barbara Guarino, Michael A. Schmid, Nicholas M. Franko, Jennifer K. Logue, Ha V. DangKevin Hauser, Julia Di Iulio, William Rivera, Gretja Schnell, Anushka Rajesh, Jiayi Zhou, Nisar Farhat, Hannah Kaiser, Martin Montiel-Rui, Julia Noack, Florian A. Lempp, Javier Janer, Rana Abdelnabi, Piet Maes, Paolo Ferrari, Alessandro Ceschi, Olivier Giannini, Guilherme Dias De Melo, Lauriane Kergoat, Hervé Bourhy, Johan Neyts, Leah Soriaga, Lisa A. Purcell, Gyorgy Snell, Sean P.J. Whelan, Antonio Lanzavecchia, Herbert W. Virgin, Luca Piccoli, Helen Y. Chu, Matteo Samuele Pizzuto, Davide Corti, David Veesler

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59 Scopus citations

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron sublineages carry distinct spike mutations resulting in escape from antibodies induced by previous infection or vaccination. We show that hybrid immunity or vaccine boosters elicit plasma-neutralizing antibodies against Omicron BA.1, BA.2, BA.2.12.1, and BA.4/5, and that breakthrough infections, but not vaccination alone, induce neutralizing antibodies in the nasal mucosa. Consistent with immunological imprinting, most antibodies derived from memory B cells or plasma cells of Omicron breakthrough cases cross-react with the Wuhan-Hu-1, BA.1, BA.2, and BA.4/5 receptor-binding domains, whereas Omicron primary infections elicit B cells of narrow specificity up to 6 months after infection. Although most clinical antibodies have reduced neutralization of Omicron, we identified an ultrapotent pan-variant-neutralizing antibody that is a strong candidate for clinical development.

Original language	English
Pages (from-to)	619-627
Number of pages	9
Journal	Science
Volume	378
Issue number	6620
DOIs	https://doi.org/10.1126/science.adc9127
State	Published - Nov 11 2022

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Park, Y. J., Pinto, D., Walls, A. C., Liu, Z., De Marco, A., Benigni, F., Zatta, F., Silacci-Fregn, C., Bassi, J., Sprouse, K. R., Addetia, A., Bowen, J. E., Stewart, C., Giurdanella, M., Saliba, C., Guarino, B., Schmid, M. A., Franko, N. M., Logue, J. K., ... Veesler, D. (2022). Imprinted antibody responses against SARS-CoV-2 Omicron sublineages. Science, 378(6620), 619-627. https://doi.org/10.1126/science.adc9127

@article{7c0bc8b33fef428d94af1b8e7a90e246,

title = "Imprinted antibody responses against SARS-CoV-2 Omicron sublineages",

abstract = "Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron sublineages carry distinct spike mutations resulting in escape from antibodies induced by previous infection or vaccination. We show that hybrid immunity or vaccine boosters elicit plasma-neutralizing antibodies against Omicron BA.1, BA.2, BA.2.12.1, and BA.4/5, and that breakthrough infections, but not vaccination alone, induce neutralizing antibodies in the nasal mucosa. Consistent with immunological imprinting, most antibodies derived from memory B cells or plasma cells of Omicron breakthrough cases cross-react with the Wuhan-Hu-1, BA.1, BA.2, and BA.4/5 receptor-binding domains, whereas Omicron primary infections elicit B cells of narrow specificity up to 6 months after infection. Although most clinical antibodies have reduced neutralization of Omicron, we identified an ultrapotent pan-variant-neutralizing antibody that is a strong candidate for clinical development.",

author = "Park, {Young Jun} and Dora Pinto and Walls, {Alexandra C.} and Zhuoming Liu and {De Marco}, Anna and Fabio Benigni and Fabrizia Zatta and Chiara Silacci-Fregn and Jessica Bassi and Sprouse, {Kaitlin R.} and Amin Addetia and Bowen, {John E.} and Cameron Stewart and Martina Giurdanella and Christian Saliba and Barbara Guarino and Schmid, {Michael A.} and Franko, {Nicholas M.} and Logue, {Jennifer K.} and Dang, {Ha V.} and Kevin Hauser and {Di Iulio}, Julia and William Rivera and Gretja Schnell and Anushka Rajesh and Jiayi Zhou and Nisar Farhat and Hannah Kaiser and Martin Montiel-Rui and Julia Noack and Lempp, {Florian A.} and Javier Janer and Rana Abdelnabi and Piet Maes and Paolo Ferrari and Alessandro Ceschi and Olivier Giannini and {De Melo}, {Guilherme Dias} and Lauriane Kergoat and Herv{\'e} Bourhy and Johan Neyts and Leah Soriaga and Purcell, {Lisa A.} and Gyorgy Snell and Whelan, {Sean P.J.} and Antonio Lanzavecchia and Virgin, {Herbert W.} and Luca Piccoli and Chu, {Helen Y.} and Pizzuto, {Matteo Samuele} and Davide Corti and David Veesler",

year = "2022",

month = nov,

day = "11",

doi = "10.1126/science.adc9127",

language = "English",

volume = "378",

pages = "619--627",

journal = "Science",

issn = "0036-8075",

number = "6620",

}

Park, YJ, Pinto, D, Walls, AC, Liu, Z, De Marco, A, Benigni, F, Zatta, F, Silacci-Fregn, C, Bassi, J, Sprouse, KR, Addetia, A, Bowen, JE, Stewart, C, Giurdanella, M, Saliba, C, Guarino, B, Schmid, MA, Franko, NM, Logue, JK, Dang, HV, Hauser, K, Di Iulio, J, Rivera, W, Schnell, G, Rajesh, A, Zhou, J, Farhat, N, Kaiser, H, Montiel-Rui, M, Noack, J, Lempp, FA, Janer, J, Abdelnabi, R, Maes, P, Ferrari, P, Ceschi, A, Giannini, O, De Melo, GD, Kergoat, L, Bourhy, H, Neyts, J, Soriaga, L, Purcell, LA, Snell, G, Whelan, SPJ, Lanzavecchia, A, Virgin, HW, Piccoli, L, Chu, HY, Pizzuto, MS, Corti, D & Veesler, D 2022, 'Imprinted antibody responses against SARS-CoV-2 Omicron sublineages', Science, vol. 378, no. 6620, pp. 619-627. https://doi.org/10.1126/science.adc9127

TY - JOUR

T1 - Imprinted antibody responses against SARS-CoV-2 Omicron sublineages

AU - Park, Young Jun

AU - Pinto, Dora

AU - Walls, Alexandra C.

AU - Liu, Zhuoming

AU - De Marco, Anna

AU - Benigni, Fabio

AU - Zatta, Fabrizia

AU - Silacci-Fregn, Chiara

AU - Bassi, Jessica

AU - Sprouse, Kaitlin R.

AU - Addetia, Amin

AU - Bowen, John E.

AU - Stewart, Cameron

AU - Giurdanella, Martina

AU - Saliba, Christian

AU - Guarino, Barbara

AU - Schmid, Michael A.

AU - Franko, Nicholas M.

AU - Logue, Jennifer K.

AU - Dang, Ha V.

AU - Hauser, Kevin

AU - Di Iulio, Julia

AU - Rivera, William

AU - Schnell, Gretja

AU - Rajesh, Anushka

AU - Zhou, Jiayi

AU - Farhat, Nisar

AU - Kaiser, Hannah

AU - Montiel-Rui, Martin

AU - Noack, Julia

AU - Lempp, Florian A.

AU - Janer, Javier

AU - Abdelnabi, Rana

AU - Maes, Piet

AU - Ferrari, Paolo

AU - Ceschi, Alessandro

AU - Giannini, Olivier

AU - De Melo, Guilherme Dias

AU - Kergoat, Lauriane

AU - Bourhy, Hervé

AU - Neyts, Johan

AU - Soriaga, Leah

AU - Purcell, Lisa A.

AU - Snell, Gyorgy

AU - Whelan, Sean P.J.

AU - Lanzavecchia, Antonio

AU - Virgin, Herbert W.

AU - Piccoli, Luca

AU - Chu, Helen Y.

AU - Pizzuto, Matteo Samuele

AU - Corti, Davide

AU - Veesler, David

PY - 2022/11/11

Y1 - 2022/11/11

N2 - Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron sublineages carry distinct spike mutations resulting in escape from antibodies induced by previous infection or vaccination. We show that hybrid immunity or vaccine boosters elicit plasma-neutralizing antibodies against Omicron BA.1, BA.2, BA.2.12.1, and BA.4/5, and that breakthrough infections, but not vaccination alone, induce neutralizing antibodies in the nasal mucosa. Consistent with immunological imprinting, most antibodies derived from memory B cells or plasma cells of Omicron breakthrough cases cross-react with the Wuhan-Hu-1, BA.1, BA.2, and BA.4/5 receptor-binding domains, whereas Omicron primary infections elicit B cells of narrow specificity up to 6 months after infection. Although most clinical antibodies have reduced neutralization of Omicron, we identified an ultrapotent pan-variant-neutralizing antibody that is a strong candidate for clinical development.

AB - Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron sublineages carry distinct spike mutations resulting in escape from antibodies induced by previous infection or vaccination. We show that hybrid immunity or vaccine boosters elicit plasma-neutralizing antibodies against Omicron BA.1, BA.2, BA.2.12.1, and BA.4/5, and that breakthrough infections, but not vaccination alone, induce neutralizing antibodies in the nasal mucosa. Consistent with immunological imprinting, most antibodies derived from memory B cells or plasma cells of Omicron breakthrough cases cross-react with the Wuhan-Hu-1, BA.1, BA.2, and BA.4/5 receptor-binding domains, whereas Omicron primary infections elicit B cells of narrow specificity up to 6 months after infection. Although most clinical antibodies have reduced neutralization of Omicron, we identified an ultrapotent pan-variant-neutralizing antibody that is a strong candidate for clinical development.

UR - http://www.scopus.com/inward/record.url?scp=85141867390&partnerID=8YFLogxK

U2 - 10.1126/science.adc9127

DO - 10.1126/science.adc9127

M3 - Article

C2 - 36264829

AN - SCOPUS:85141867390

SN - 0036-8075

VL - 378

SP - 619

EP - 627

JO - Science

JF - Science

IS - 6620

ER -

Imprinted antibody responses against SARS-CoV-2 Omicron sublineages

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