Importance of site of infection and antibiotic selection in the treatment of carbapenem-resistant Pseudomonas aeruginosa Sepsis

Nicholas S. Britt, David J. Ritchie, Marin H. Kollef, Carey Ann D. Burnham, Michael J. Durkin, Nicholas B. Hampton, Scott T. Micek

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

In a retrospective analysis of 215 patients with carbapenem-resistant Pseudomonas aeruginosa sepsis, we observed a significantly higher risk of mortality associated with respiratory tract infection (risk ratio [RR], 1.20; 95% confidence interval [CI], 1.04 to 1.39; P = 0.010) and lower risk with urinary tract infection (RR, 0.80; 95% CI, 0.71 to 0.90; P = 0.004). Aminoglycoside monotherapy was associated with increased mortality, even after adjusting for confounders (adjusted RR, 1.72; 95% CI, 1.03 to 2.85; P = 0.037), consistent across multiple sites of infection.

Original languageEnglish
Article numbere02400-17
JournalAntimicrobial agents and chemotherapy
Volume62
Issue number4
DOIs
StatePublished - Apr 2018

Keywords

  • Carbapenem resistance
  • Multidrug resistance
  • Pseudomonas aeruginosa
  • Sepsis

Fingerprint Dive into the research topics of 'Importance of site of infection and antibiotic selection in the treatment of carbapenem-resistant Pseudomonas aeruginosa Sepsis'. Together they form a unique fingerprint.

  • Cite this