TY - JOUR
T1 - Importance of site of infection and antibiotic selection in the treatment of carbapenem-resistant Pseudomonas aeruginosa Sepsis
AU - Britt, Nicholas S.
AU - Ritchie, David J.
AU - Kollef, Marin H.
AU - Burnham, Carey Ann D.
AU - Durkin, Michael J.
AU - Hampton, Nicholas B.
AU - Micek, Scott T.
N1 - Publisher Copyright:
Copyright © 2018 American Society for Microbiology. All Rights Reserved.
PY - 2018/4
Y1 - 2018/4
N2 - In a retrospective analysis of 215 patients with carbapenem-resistant Pseudomonas aeruginosa sepsis, we observed a significantly higher risk of mortality associated with respiratory tract infection (risk ratio [RR], 1.20; 95% confidence interval [CI], 1.04 to 1.39; P = 0.010) and lower risk with urinary tract infection (RR, 0.80; 95% CI, 0.71 to 0.90; P = 0.004). Aminoglycoside monotherapy was associated with increased mortality, even after adjusting for confounders (adjusted RR, 1.72; 95% CI, 1.03 to 2.85; P = 0.037), consistent across multiple sites of infection.
AB - In a retrospective analysis of 215 patients with carbapenem-resistant Pseudomonas aeruginosa sepsis, we observed a significantly higher risk of mortality associated with respiratory tract infection (risk ratio [RR], 1.20; 95% confidence interval [CI], 1.04 to 1.39; P = 0.010) and lower risk with urinary tract infection (RR, 0.80; 95% CI, 0.71 to 0.90; P = 0.004). Aminoglycoside monotherapy was associated with increased mortality, even after adjusting for confounders (adjusted RR, 1.72; 95% CI, 1.03 to 2.85; P = 0.037), consistent across multiple sites of infection.
KW - Carbapenem resistance
KW - Multidrug resistance
KW - Pseudomonas aeruginosa
KW - Sepsis
UR - http://www.scopus.com/inward/record.url?scp=85044515525&partnerID=8YFLogxK
U2 - 10.1128/AAC.02400-17
DO - 10.1128/AAC.02400-17
M3 - Article
C2 - 29378722
AN - SCOPUS:85044515525
SN - 0066-4804
VL - 62
JO - Antimicrobial agents and chemotherapy
JF - Antimicrobial agents and chemotherapy
IS - 4
M1 - e02400-17
ER -