Abstract
Circadian rhythms are generated by well-conserved interlocked transcriptional feedback loops that involve clock genes. A growing body of research suggests that there is biological crosstalk between circadian rhythm and metabolism. We recently found that the key NAD biosynthetic enzyme, nicotinamide phosphoribosyltransferase (NAMPT), and NAD-dependent deacetylase SIRT1 play a critical role in such crosstalk, by creating a novel feedback loop in which NAD functions as a "metabolic oscillator". This review aims to summarize recent progress in elucidating the pathophysiological importance of clock genes, NAMPT-mediated NAD biosynthesis, and SIRT1, in the crosstalk between circadian rhythm and metabolism.
Original language | English |
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Pages (from-to) | 2187-2193 |
Number of pages | 7 |
Journal | Unknown Journal |
Volume | 71 |
Issue number | 12 |
State | Published - Dec 2013 |