TY - JOUR
T1 - Implications of Tumor Clonal Heterogeneity in the Era of Next-Generation Sequencing
AU - Jacoby, Meagan A.
AU - Duncavage, Eric J.
AU - Walter, Matthew J.
N1 - Publisher Copyright:
© 2015 Elsevier Inc.
PY - 2015/12/1
Y1 - 2015/12/1
N2 - Recent whole-genome sequencing (WGS) studies have demonstrated that tumors typically comprise a founding clone and multiple subclones (i.e., clonal heterogeneity is common). The possible combination of mutations in each tumor clone is enormous, making each tumor genetically unique. Clonal heterogeneity likely has a role in cancer progression, relapse, metastasis, and chemoresistance due to functional differences in genetically unique subclones. In current clinical practice, gene mutations are only classified as being present or absent, ignoring the clonal complexity of cancers. In this review, we address how tumor clonality is measured using next-generation sequencing (NGS) data, highlight that clonal heterogeneity is common across multiple tumor types, and discuss the potential clinical implications of tumor clonal heterogeneity.
AB - Recent whole-genome sequencing (WGS) studies have demonstrated that tumors typically comprise a founding clone and multiple subclones (i.e., clonal heterogeneity is common). The possible combination of mutations in each tumor clone is enormous, making each tumor genetically unique. Clonal heterogeneity likely has a role in cancer progression, relapse, metastasis, and chemoresistance due to functional differences in genetically unique subclones. In current clinical practice, gene mutations are only classified as being present or absent, ignoring the clonal complexity of cancers. In this review, we address how tumor clonality is measured using next-generation sequencing (NGS) data, highlight that clonal heterogeneity is common across multiple tumor types, and discuss the potential clinical implications of tumor clonal heterogeneity.
UR - http://www.scopus.com/inward/record.url?scp=84957798420&partnerID=8YFLogxK
U2 - 10.1016/j.trecan.2015.10.006
DO - 10.1016/j.trecan.2015.10.006
M3 - Review article
C2 - 28741514
AN - SCOPUS:84957798420
VL - 1
SP - 231
EP - 241
JO - Trends in Cancer
JF - Trends in Cancer
SN - 2405-8033
IS - 4
ER -