TY - JOUR
T1 - Implications of the PEGASUS-TIMI 54 trial for US clinical practice
AU - Bradley, Steven M.
AU - Hess, Gregory P.
AU - Stewart, Patrick
AU - Armstrong, Ehrin J.
AU - Farmer, Steven A.
AU - Wasfy, Jason H.
AU - Valle, Javier Alfonso
AU - Sandhu, Amneet
AU - Maddox, Thomas M.
N1 - Publisher Copyright:
© Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.
PY - 2017/4/1
Y1 - 2017/4/1
N2 - Objectives This study aims to determine the proportion of real-world patients with myocardial infarction (MI) who would have been eligible for the PEGASUS-TIMI 54 (Prevention of Cardiovascular Events in Patients with Prior Heart Attack Using Ticagrelor Compared to Placebo on a Background of Aspirin-Thrombolysis in Myocardial Infarction 54) trial, to characterise their current use of P2Y 12 inhibitors and to explore the estimated costs and ischaemic event consequences of increasing P2Y 12 inhibitor use among these patients. Methods In the US national ACTION Registry-GWTG (Acute Coronary Treatment and Intervention Outcomes Network Registry-Get With The Guidelines), we identified 273 328 patients with MI and determined the proportion that would have met the eligibility criteria for the PEGASUS trial. We described longitudinal P2Y 12 inhibitor use among patients eligible for PEGASUS and estimated the cost and ischaemic consequences of increasing P2Y 12 use among eligible patients. Results A total of 112 222 (41.1%) patients with MI in ACTION Registry-GWTG met eligibility for the PEGASUS trial. Among 83 871 eligible patients with pharmacy claims data, 23 042 (27.5%) were on a P2Y 12 inhibitor at 1 year, 9661 (11.5%) at 2 years and 5246 (6.3%) at 3 years, with the majority (79.2%) of these patients on clopidogrel. The use of ticagrelor in eligible patients not yet on a P2Y 12 inhibitor at 1 year post-MI would cost an estimated US$885 000 per MI, stroke or cardiovascular death averted over a 3-year time horizon, while the use of clopidogrel would cost an estimated US$19 800 per ischaemic event averted. Conclusion In contemporary clinical practice, a minority of patients are on a P2Y 12 inhibitor beyond 1-year post-MI. Applying PEGASUS trial findings to clinical practice would result in a large increase in P2Y 12 inhibitor use, with a cost per ischaemic event averted that is strongly influenced by the choice of therapy.
AB - Objectives This study aims to determine the proportion of real-world patients with myocardial infarction (MI) who would have been eligible for the PEGASUS-TIMI 54 (Prevention of Cardiovascular Events in Patients with Prior Heart Attack Using Ticagrelor Compared to Placebo on a Background of Aspirin-Thrombolysis in Myocardial Infarction 54) trial, to characterise their current use of P2Y 12 inhibitors and to explore the estimated costs and ischaemic event consequences of increasing P2Y 12 inhibitor use among these patients. Methods In the US national ACTION Registry-GWTG (Acute Coronary Treatment and Intervention Outcomes Network Registry-Get With The Guidelines), we identified 273 328 patients with MI and determined the proportion that would have met the eligibility criteria for the PEGASUS trial. We described longitudinal P2Y 12 inhibitor use among patients eligible for PEGASUS and estimated the cost and ischaemic consequences of increasing P2Y 12 use among eligible patients. Results A total of 112 222 (41.1%) patients with MI in ACTION Registry-GWTG met eligibility for the PEGASUS trial. Among 83 871 eligible patients with pharmacy claims data, 23 042 (27.5%) were on a P2Y 12 inhibitor at 1 year, 9661 (11.5%) at 2 years and 5246 (6.3%) at 3 years, with the majority (79.2%) of these patients on clopidogrel. The use of ticagrelor in eligible patients not yet on a P2Y 12 inhibitor at 1 year post-MI would cost an estimated US$885 000 per MI, stroke or cardiovascular death averted over a 3-year time horizon, while the use of clopidogrel would cost an estimated US$19 800 per ischaemic event averted. Conclusion In contemporary clinical practice, a minority of patients are on a P2Y 12 inhibitor beyond 1-year post-MI. Applying PEGASUS trial findings to clinical practice would result in a large increase in P2Y 12 inhibitor use, with a cost per ischaemic event averted that is strongly influenced by the choice of therapy.
KW - P2Y 12
KW - cost
KW - myocardial infarction
KW - secondary prevention
UR - http://www.scopus.com/inward/record.url?scp=85019034590&partnerID=8YFLogxK
U2 - 10.1136/openhrt-2016-000580
DO - 10.1136/openhrt-2016-000580
M3 - Article
AN - SCOPUS:85019034590
SN - 2398-595X
VL - 4
JO - Open Heart
JF - Open Heart
IS - 1
M1 - e000580
ER -