Implantable biomaterial based on click chemistry for targeting small molecules

José M. Mejía Oneto, Munish Gupta, J. Kent Leach, Mark Lee, Julie L. Sutcliffe

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

Specific and targeted delivery of medical therapies continues to be a challenge for the optimal treatment of multiple medical conditions. Technological advances permit physicians to target most sites of the body. However, after the intervention, physicians rely on systemic medications that need frequent dosing and may have noxious side effects. A novel system combining the temporal flexibility of systemic drug delivery and the spatial control of injectable biomaterials would improve the spatiotemporal control of medical therapies. Here we present an implantable biomaterial that harnesses in vivo click chemistry to enhance the delivery of suitable small molecules by an order of magnitude. The results demonstrate a simple and modular method to modify a biomaterial with small molecules in vitro and present an example of a polysaccharide modified hours after in vivo implantation. This approach provides the ability to precisely control the moment when biochemical and/or physical signals may appear in an implanted biomaterial. This is the first step towards the construction of a biomaterial that enhances the spatial location of systemic small molecules via in vivo chemical delivery.

Original languageEnglish
Pages (from-to)5099-5105
Number of pages7
JournalActa Biomaterialia
Volume10
Issue number12
DOIs
StatePublished - Jan 1 2014
Externally publishedYes

Keywords

  • Alginate
  • Click chemistry
  • Drug delivery
  • Hydrogel
  • In vivo imaging

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