Impaired protein aggregate handling and clearance underlie the pathogenesis of p97/VCP-associated disease

Keyphrases

• Frontotemporal Dementia 100%
• Paget's Disease of Bone 100%
• Associated Diseases 100%
• Protein Aggregates 100%
• Inclusion Body Myopathy 100%
• Aggresome 50%
• Small Inclusion 50%
• Protein Degradation 33%
• Mutant Cells 33%
• Polyglutamine 33%
• Histone Deacetylase 6 (HDAC6) 33%
• Pathological Features 16%
• Proteasome Inhibition 16%
• Co-expression 16%
• Cellular Processes 16%
• Protein Family 16%
• Binding Protein 16%
• Multisystem Disease 16%
• ATP Synthase 16%
• Autophagic Degradation 16%
• Degenerative Disease 16%
• Aggregated Protein 16%
• Autophagy Machinery 16%
• Induced Cell Death 16%
• Inclusion Bodies 16%
• Aggregate-prone Proteins 16%
• Therapeutic Benefits 16%
• Ubiquitinated Proteins 16%
• AAA+ 16%
• Inclusion Body Formation 16%

Neuroscience

• Frontotemporal Dementia 100%
• Protein Aggregate 100%
• Muscle Disorder 100%
• Aggresome 50%
• Polyglutamine 33%
• Histone Deacetylase 6 33%
• Cell Death 16%
• Protein Binding 16%
• Autophagy 16%
• Proteasome 16%
• Adenosine Triphosphatase 16%
• Protein Family 16%
• Ubiquitinated Protein 16%

Biochemistry, Genetics and Molecular Biology

• P97 100%
• Aggresome 60%
• Cell Mutant 40%
• HDAC6 40%
• Cell Death 20%
• Binding Protein 20%
• Protein Family 20%
• Autophagy 20%
• Protein Catabolism 20%
• Proteasome 20%
• ATPase 20%
• AAA+ 20%