Impaired Parathyroid Hormone Metabolism in Patients with Chronic Renal Failure

Jeffrey Freitag, Kevin J. Martin, Keith A. Hruska, Charles Anderson, Mollie Conrades, Jack Ladenson, Saulo Klahr, Eduardo Slatopolsky

Research output: Contribution to journalArticlepeer-review

114 Scopus citations


SECONDARY hyperparathyroidism, with markedly elevated levels of circulating parathyroid hormone, is a universal complication of chronic renal failure.1,2 Increased secretion has been accepted as the underlying mechanism responsible for the high levels of parathyroid hormone seen in uremic subjects. Multiple factors have been implicated in the pathogenesis of parathyroid hormone hypersecretion in chronic renal disease, including phosphate retention,3 impaired production of 1,25-dihydroxycholecalciferol4 leading to impaired intestinal calcium absorption,5,6 and skeletal resistance to the action of parathyroid hormone.7,8 In recent years, the importance of the kidney in the metabolism of parathyroid hormone has been recognized. Berson and Yalow9 demonstrated a prolonged.

Original languageEnglish
Pages (from-to)29-32
Number of pages4
JournalNew England Journal of Medicine
Issue number1
StatePublished - Jan 5 1978


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