Impaired Parathyroid Hormone Metabolism in Patients with Chronic Renal Failure

Jeffrey Freitag; Kevin J. Martin; Keith A. Hruska; Charles Anderson; Mollie Conrades; Jack Ladenson; Saulo Klahr; Eduardo Slatopolsky

doi:10.1056/NEJM197801052980107

Impaired Parathyroid Hormone Metabolism in Patients with Chronic Renal Failure

Jeffrey Freitag, Kevin J. Martin, Keith A. Hruska, Charles Anderson, Mollie Conrades, Jack Ladenson, Saulo Klahr, Eduardo Slatopolsky

Research output: Contribution to journal › Article › peer-review

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Abstract

SECONDARY hyperparathyroidism, with markedly elevated levels of circulating parathyroid hormone, is a universal complication of chronic renal failure.¹^,² Increased secretion has been accepted as the underlying mechanism responsible for the high levels of parathyroid hormone seen in uremic subjects. Multiple factors have been implicated in the pathogenesis of parathyroid hormone hypersecretion in chronic renal disease, including phosphate retention,³ impaired production of 1,25-dihydroxycholecalciferol⁴ leading to impaired intestinal calcium absorption,⁵^,⁶ and skeletal resistance to the action of parathyroid hormone.⁷^,⁸ In recent years, the importance of the kidney in the metabolism of parathyroid hormone has been recognized. Berson and Yalow⁹ demonstrated a prolonged.

Original language	English
Pages (from-to)	29-32
Number of pages	4
Journal	New England Journal of Medicine
Volume	298
Issue number	1
DOIs	https://doi.org/10.1056/NEJM197801052980107
State	Published - Jan 5 1978

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title = "Impaired Parathyroid Hormone Metabolism in Patients with Chronic Renal Failure",

abstract = "SECONDARY hyperparathyroidism, with markedly elevated levels of circulating parathyroid hormone, is a universal complication of chronic renal failure.1,2 Increased secretion has been accepted as the underlying mechanism responsible for the high levels of parathyroid hormone seen in uremic subjects. Multiple factors have been implicated in the pathogenesis of parathyroid hormone hypersecretion in chronic renal disease, including phosphate retention,3 impaired production of 1,25-dihydroxycholecalciferol4 leading to impaired intestinal calcium absorption,5,6 and skeletal resistance to the action of parathyroid hormone.7,8 In recent years, the importance of the kidney in the metabolism of parathyroid hormone has been recognized. Berson and Yalow9 demonstrated a prolonged.",

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AU - Freitag, Jeffrey

AU - Martin, Kevin J.

AU - Hruska, Keith A.

AU - Anderson, Charles

AU - Conrades, Mollie

AU - Ladenson, Jack

AU - Klahr, Saulo

AU - Slatopolsky, Eduardo

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N2 - SECONDARY hyperparathyroidism, with markedly elevated levels of circulating parathyroid hormone, is a universal complication of chronic renal failure.1,2 Increased secretion has been accepted as the underlying mechanism responsible for the high levels of parathyroid hormone seen in uremic subjects. Multiple factors have been implicated in the pathogenesis of parathyroid hormone hypersecretion in chronic renal disease, including phosphate retention,3 impaired production of 1,25-dihydroxycholecalciferol4 leading to impaired intestinal calcium absorption,5,6 and skeletal resistance to the action of parathyroid hormone.7,8 In recent years, the importance of the kidney in the metabolism of parathyroid hormone has been recognized. Berson and Yalow9 demonstrated a prolonged.

AB - SECONDARY hyperparathyroidism, with markedly elevated levels of circulating parathyroid hormone, is a universal complication of chronic renal failure.1,2 Increased secretion has been accepted as the underlying mechanism responsible for the high levels of parathyroid hormone seen in uremic subjects. Multiple factors have been implicated in the pathogenesis of parathyroid hormone hypersecretion in chronic renal disease, including phosphate retention,3 impaired production of 1,25-dihydroxycholecalciferol4 leading to impaired intestinal calcium absorption,5,6 and skeletal resistance to the action of parathyroid hormone.7,8 In recent years, the importance of the kidney in the metabolism of parathyroid hormone has been recognized. Berson and Yalow9 demonstrated a prolonged.

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Impaired Parathyroid Hormone Metabolism in Patients with Chronic Renal Failure

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