Impaired Oxygen on-Kinetics in Persons with Human Immunodeficiency Virus Are Not Due to Highly Active Antiretroviral Therapy

W. Todd Cade, Lori E. Fantry, Sharmila R. Nabar, Donald K. Shaw, Randall E. Keyser

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

Objective: To determine the effects of human immunodeficiency virus (HIV) and highly active antiretroviral therapy (HAART) on oxygen on-kinetics in HIV-positive persons. Design: Quasi-experimental cross-sectional. Setting: Infectious disease clinic and exercise laboratory. Participants: Referred participants (N=39) included 13 HIV-positive participants taking HAART, 13 HIV-positive participants not taking HAART, and 13 noninfected controls. Interventions: Participants performed 1 submaximal exercise treadmill test below the ventilatory threshold, 1 above the ventilatory threshold, and 1 maximal treadmill exercise test to exhaustion. Main Outcome Measures: Change in oxygen consumption (ΔV̇O2) and oxidative response index (ΔV̇O2/mean response time). Results: ΔV̇O 2 was significantly lower in both HIV-positive participants taking (946.5±68.1mL) and not taking (871.6±119.6mL) HAART than in controls (1265.3±99.8mL) during submaximal exercise above the ventilatory threshold. The oxidative response index was also significantly lower (P<.05) in HIV-positive participants both taking (15.0±1.3mL/s) and not taking (15.1±1.7mL/s) HAART than in controls (20.8± 2.1mL/s) during exercise above the ventilatory threshold. Conclusion: Oxygen on-kinetics during submaximal exercise above the ventilatory threshold was impaired in HIV-positive participants compared with a control group, and it appeared that the attenuated oxygen on-kinetic response was primarily caused by HIV infection rather than HAART.

Original languageEnglish
Pages (from-to)1831-1838
Number of pages8
JournalArchives of Physical Medicine and Rehabilitation
Volume84
Issue number12
DOIs
StatePublished - Dec 2003

Keywords

  • Exercise
  • HIV
  • Kinetics
  • Oxygen
  • Rehabilitation

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