Impact of Toll-Like Receptor 4 Signaling in Necrotizing Enterocolitis: The State of the Science

Belgacem Mihi, Misty Good

Research output: Contribution to journalReview article

8 Scopus citations

Abstract

Necrotizing enterocolitis (NEC) remains a leading cause of preterm infant mortality. NEC is multifactorial and believed a consequence of intestinal immaturity, microbial dysbiosis, and an exuberant inflammatory response. Over the past decade, exaggerated Toll-like receptor 4 (TLR4) activity in the immature intestine of preterm neonates emerged as an inciting event preceding NEC. Increased TLR4 signaling in epithelial cells results in the initiation of an uncontrolled immune response and destruction of the mucosal barrier. This article discusses the state of the science of the molecular mechanisms involved in TLR4-mediated inflammation during NEC and the development of new therapeutic strategies to prevent NEC.

Original languageEnglish
Pages (from-to)145-157
Number of pages13
JournalClinics in Perinatology
Volume46
Issue number1
DOIs
StatePublished - Mar 2019

Keywords

  • Epithelial cells
  • Inflammation
  • Necrotizing enterocolitis
  • TLR4

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