Impact of Sex on Cardiovascular Adaptations to Exercise: JACC Review Topic of the Week

Bradley J. Petek; Eugene H. Chung; Jonathan H. Kim; Rachel Lampert; Benjamin D. Levine; Dermot Phelan; Alfred Danielian; Peter N. Dean; Elizabeth H. Dineen; Antonio B. Fernandez; Mustafa Husaini; Sheela Krishnan; Ankit B. Shah; Katie M. Stewart; Meagan M. Wasfy

doi:10.1016/j.jacc.2023.05.070

Impact of Sex on Cardiovascular Adaptations to Exercise: JACC Review Topic of the Week

Bradley J. Petek, Eugene H. Chung, Jonathan H. Kim, Rachel Lampert, Benjamin D. Levine, Dermot Phelan, Alfred Danielian, Peter N. Dean, Elizabeth H. Dineen, Antonio B. Fernandez, Mustafa Husaini, Sheela Krishnan, Ankit B. Shah, Katie M. Stewart, Meagan M. Wasfy

Research output: Contribution to journal › Review article › peer-review

11 Scopus citations

Abstract

Routine exercise leads to cardiovascular adaptations that differ based on sex. Use of cardiac testing to screen athletes has driven research to define how these sex-based adaptations manifest on the electrocardiogram and cardiac imaging. Importantly, sex-based differences in cardiovascular structure and outcomes in athletes often parallel findings in the general population, underscoring the importance of understanding their mechanisms. Substantial gaps exist in the understanding of why cardiovascular adaptations and outcomes related to exercise differ by sex because of underrepresentation of female participants in research. As female sports participation rates have increased dramatically over several decades, it also remains unknown if differences observed in older athletes reflect biological mechanisms vs less lifetime access to sports in females. In this review, we will assess the effect of sex on cardiovascular adaptations and outcomes related to exercise, identify the impact of sex hormones on exercise performance, and highlight key areas for future research.

Original language	English
Pages (from-to)	1030-1038
Number of pages	9
Journal	Journal of the American College of Cardiology
Volume	82
Issue number	10
DOIs	https://doi.org/10.1016/j.jacc.2023.05.070
State	Published - Sep 5 2023

Keywords

athlete
cardiovascular remodeling
female
physical activity

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10.1016/j.jacc.2023.05.070

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Petek, B. J., Chung, E. H., Kim, J. H., Lampert, R., Levine, B. D., Phelan, D., Danielian, A., Dean, P. N., Dineen, E. H., Fernandez, A. B., Husaini, M., Krishnan, S., Shah, A. B., Stewart, K. M., & Wasfy, M. M. (2023). Impact of Sex on Cardiovascular Adaptations to Exercise: JACC Review Topic of the Week. Journal of the American College of Cardiology, 82(10), 1030-1038. https://doi.org/10.1016/j.jacc.2023.05.070

@article{9db625da66ba433c8dbb630ffa9c9940,

title = "Impact of Sex on Cardiovascular Adaptations to Exercise: JACC Review Topic of the Week",

abstract = "Routine exercise leads to cardiovascular adaptations that differ based on sex. Use of cardiac testing to screen athletes has driven research to define how these sex-based adaptations manifest on the electrocardiogram and cardiac imaging. Importantly, sex-based differences in cardiovascular structure and outcomes in athletes often parallel findings in the general population, underscoring the importance of understanding their mechanisms. Substantial gaps exist in the understanding of why cardiovascular adaptations and outcomes related to exercise differ by sex because of underrepresentation of female participants in research. As female sports participation rates have increased dramatically over several decades, it also remains unknown if differences observed in older athletes reflect biological mechanisms vs less lifetime access to sports in females. In this review, we will assess the effect of sex on cardiovascular adaptations and outcomes related to exercise, identify the impact of sex hormones on exercise performance, and highlight key areas for future research.",

keywords = "athlete, cardiovascular remodeling, female, physical activity",

author = "Petek, {Bradley J.} and Chung, {Eugene H.} and Kim, {Jonathan H.} and Rachel Lampert and Levine, {Benjamin D.} and Dermot Phelan and Alfred Danielian and Dean, {Peter N.} and Dineen, {Elizabeth H.} and Fernandez, {Antonio B.} and Mustafa Husaini and Sheela Krishnan and Shah, {Ankit B.} and Stewart, {Katie M.} and Wasfy, {Meagan M.}",

note = "Publisher Copyright: {\textcopyright} 2023 American College of Cardiology Foundation",

year = "2023",

month = sep,

day = "5",

doi = "10.1016/j.jacc.2023.05.070",

language = "English",

volume = "82",

pages = "1030--1038",

journal = "Journal of the American College of Cardiology",

issn = "0735-1097",

number = "10",

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Petek, BJ, Chung, EH, Kim, JH, Lampert, R, Levine, BD, Phelan, D, Danielian, A, Dean, PN, Dineen, EH, Fernandez, AB, Husaini, M, Krishnan, S, Shah, AB, Stewart, KM & Wasfy, MM 2023, 'Impact of Sex on Cardiovascular Adaptations to Exercise: JACC Review Topic of the Week', Journal of the American College of Cardiology, vol. 82, no. 10, pp. 1030-1038. https://doi.org/10.1016/j.jacc.2023.05.070

TY - JOUR

T1 - Impact of Sex on Cardiovascular Adaptations to Exercise

T2 - JACC Review Topic of the Week

AU - Petek, Bradley J.

AU - Chung, Eugene H.

AU - Kim, Jonathan H.

AU - Lampert, Rachel

AU - Levine, Benjamin D.

AU - Phelan, Dermot

AU - Danielian, Alfred

AU - Dean, Peter N.

AU - Dineen, Elizabeth H.

AU - Fernandez, Antonio B.

AU - Husaini, Mustafa

AU - Krishnan, Sheela

AU - Shah, Ankit B.

AU - Stewart, Katie M.

AU - Wasfy, Meagan M.

PY - 2023/9/5

Y1 - 2023/9/5

N2 - Routine exercise leads to cardiovascular adaptations that differ based on sex. Use of cardiac testing to screen athletes has driven research to define how these sex-based adaptations manifest on the electrocardiogram and cardiac imaging. Importantly, sex-based differences in cardiovascular structure and outcomes in athletes often parallel findings in the general population, underscoring the importance of understanding their mechanisms. Substantial gaps exist in the understanding of why cardiovascular adaptations and outcomes related to exercise differ by sex because of underrepresentation of female participants in research. As female sports participation rates have increased dramatically over several decades, it also remains unknown if differences observed in older athletes reflect biological mechanisms vs less lifetime access to sports in females. In this review, we will assess the effect of sex on cardiovascular adaptations and outcomes related to exercise, identify the impact of sex hormones on exercise performance, and highlight key areas for future research.

AB - Routine exercise leads to cardiovascular adaptations that differ based on sex. Use of cardiac testing to screen athletes has driven research to define how these sex-based adaptations manifest on the electrocardiogram and cardiac imaging. Importantly, sex-based differences in cardiovascular structure and outcomes in athletes often parallel findings in the general population, underscoring the importance of understanding their mechanisms. Substantial gaps exist in the understanding of why cardiovascular adaptations and outcomes related to exercise differ by sex because of underrepresentation of female participants in research. As female sports participation rates have increased dramatically over several decades, it also remains unknown if differences observed in older athletes reflect biological mechanisms vs less lifetime access to sports in females. In this review, we will assess the effect of sex on cardiovascular adaptations and outcomes related to exercise, identify the impact of sex hormones on exercise performance, and highlight key areas for future research.

KW - athlete

KW - cardiovascular remodeling

KW - female

KW - physical activity

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U2 - 10.1016/j.jacc.2023.05.070

DO - 10.1016/j.jacc.2023.05.070

M3 - Review article

C2 - 37648352

AN - SCOPUS:85168621729

SN - 0735-1097

VL - 82

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EP - 1038

JO - Journal of the American College of Cardiology

JF - Journal of the American College of Cardiology

IS - 10

ER -

Impact of Sex on Cardiovascular Adaptations to Exercise: JACC Review Topic of the Week

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Keywords

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