TY - JOUR
T1 - Impact of Semi-Annual Albendazole on Lymphatic Filariasis and Soil-Transmitted Helminth Infection
T2 - Parasitological Assessment after 14 Rounds of Community Treatment
AU - Pion, Sébastien D.S.
AU - Chesnais, Cédric B.
AU - Weil, Gary J.
AU - Louya, Frédéric
AU - Boussinesq, Michel
AU - Missamou, François
N1 - Publisher Copyright:
© 2022 by The American Society of Tropical Medicine and Hygiene.
PY - 2022/2
Y1 - 2022/2
N2 - Between October 2012 and October 2015, we conducted a community trial to assess the impact of semi-annual (twice yearly) community treatment with albendazole on lymphatic filariasis in Seke Pembe, a village in the Republic of the Congo. Semi-annual community treatment with albendazole has been continued in the community since October 2015. We conducted an additional parasitological assessment survey in October 2019, 6 months after the 14th round of semi-annual treatment. Between October 2012 and October 2015, Wuchereria bancrofti antigenemia and microfilaremia rates in the community had decreased from 17.3%to 4.7%and from 5.3%to 0.3%, respectively. In October 2019, the antigenemia rate had decreased further to 2.8% (19 of 687). No microfilariae were found in night blood smears from persons with circulating filarial antigenemia (0 of 16), suggesting that W. bancrofti transmission has been interrupted in Seke Pembe. Semi-annual albendazole treatments also reduced significantly infection rates with soiltransmitted helminths.
AB - Between October 2012 and October 2015, we conducted a community trial to assess the impact of semi-annual (twice yearly) community treatment with albendazole on lymphatic filariasis in Seke Pembe, a village in the Republic of the Congo. Semi-annual community treatment with albendazole has been continued in the community since October 2015. We conducted an additional parasitological assessment survey in October 2019, 6 months after the 14th round of semi-annual treatment. Between October 2012 and October 2015, Wuchereria bancrofti antigenemia and microfilaremia rates in the community had decreased from 17.3%to 4.7%and from 5.3%to 0.3%, respectively. In October 2019, the antigenemia rate had decreased further to 2.8% (19 of 687). No microfilariae were found in night blood smears from persons with circulating filarial antigenemia (0 of 16), suggesting that W. bancrofti transmission has been interrupted in Seke Pembe. Semi-annual albendazole treatments also reduced significantly infection rates with soiltransmitted helminths.
UR - http://www.scopus.com/inward/record.url?scp=85124487913&partnerID=8YFLogxK
U2 - 10.4269/ajtmh.21-0731
DO - 10.4269/ajtmh.21-0731
M3 - Article
C2 - 34929673
AN - SCOPUS:85124487913
VL - 106
SP - 729
EP - 731
JO - American Journal of Tropical Medicine and Hygiene
JF - American Journal of Tropical Medicine and Hygiene
SN - 0002-9637
IS - 2
ER -