Impact of reversible trapping of tracer and the presence of blood metabolites on measurements of myocardial glucose utilization performed by PET and 18F-fluorodeoxyglucose using the Patlak method

Pilar Herrero; Carmen S. Dence; Terry L. Sharp; Michael J. Welch; Robert J. Gropler

doi:10.1016/j.nucmedbio.2004.03.002

Impact of reversible trapping of tracer and the presence of blood metabolites on measurements of myocardial glucose utilization performed by PET and ¹⁸F-fluorodeoxyglucose using the Patlak method

Pilar Herrero, Carmen S. Dence, Terry L. Sharp, Michael J. Welch, Robert J. Gropler

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

In this study we demonstrated that significant egress of FDG from myocardium occurs within the first hour after tracer injection leading to nonlinear Patlak plots. There are also significant amounts of acidic FDG metabolites present in the blood. However, the impact of these metabolites on the estimates of myocardial glucose utilization (MGU) is negligible. Although further studies will be required to elucidate the reason for the egress of tracer from myocardium, not accounting for it will result in erroneous estimates of MGU.

Original language	English
Pages (from-to)	883-892
Number of pages	10
Journal	Nuclear Medicine and Biology
Volume	31
Issue number	7
DOIs	https://doi.org/10.1016/j.nucmedbio.2004.03.002
State	Published - Oct 2004

Keywords

FDG
Metabolism
Myocardium
Tomography

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10.1016/j.nucmedbio.2004.03.002

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Herrero, P., Dence, C. S., Sharp, T. L., Welch, M. J., & Gropler, R. J. (2004). Impact of reversible trapping of tracer and the presence of blood metabolites on measurements of myocardial glucose utilization performed by PET and ¹⁸F-fluorodeoxyglucose using the Patlak method. Nuclear Medicine and Biology, 31(7), 883-892. https://doi.org/10.1016/j.nucmedbio.2004.03.002

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title = "Impact of reversible trapping of tracer and the presence of blood metabolites on measurements of myocardial glucose utilization performed by PET and 18F-fluorodeoxyglucose using the Patlak method",

abstract = "In this study we demonstrated that significant egress of FDG from myocardium occurs within the first hour after tracer injection leading to nonlinear Patlak plots. There are also significant amounts of acidic FDG metabolites present in the blood. However, the impact of these metabolites on the estimates of myocardial glucose utilization (MGU) is negligible. Although further studies will be required to elucidate the reason for the egress of tracer from myocardium, not accounting for it will result in erroneous estimates of MGU.",

keywords = "FDG, Metabolism, Myocardium, Tomography",

author = "Pilar Herrero and Dence, {Carmen S.} and Sharp, {Terry L.} and Welch, {Michael J.} and Gropler, {Robert J.}",

note = "Funding Information: This work was supported by NIH Grant No. HL13581. the authors thank John Engelbach, Mark Nolte, Margaret Morris, Linda Wiley-Becker, and William Margeneau for their technical assistance and Mary Russo for her administrative assistance. ",

year = "2004",

month = oct,

doi = "10.1016/j.nucmedbio.2004.03.002",

language = "English",

volume = "31",

pages = "883--892",

journal = "Nuclear Medicine and Biology",

issn = "0969-8051",

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Impact of reversible trapping of tracer and the presence of blood metabolites on measurements of myocardial glucose utilization performed by PET and ¹⁸F-fluorodeoxyglucose using the Patlak method. / Herrero, Pilar; Dence, Carmen S.; Sharp, Terry L. et al.
In: Nuclear Medicine and Biology, Vol. 31, No. 7, 10.2004, p. 883-892.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Impact of reversible trapping of tracer and the presence of blood metabolites on measurements of myocardial glucose utilization performed by PET and 18F-fluorodeoxyglucose using the Patlak method

AU - Herrero, Pilar

AU - Dence, Carmen S.

AU - Sharp, Terry L.

AU - Welch, Michael J.

AU - Gropler, Robert J.

N1 - Funding Information: This work was supported by NIH Grant No. HL13581. the authors thank John Engelbach, Mark Nolte, Margaret Morris, Linda Wiley-Becker, and William Margeneau for their technical assistance and Mary Russo for her administrative assistance.

PY - 2004/10

Y1 - 2004/10

N2 - In this study we demonstrated that significant egress of FDG from myocardium occurs within the first hour after tracer injection leading to nonlinear Patlak plots. There are also significant amounts of acidic FDG metabolites present in the blood. However, the impact of these metabolites on the estimates of myocardial glucose utilization (MGU) is negligible. Although further studies will be required to elucidate the reason for the egress of tracer from myocardium, not accounting for it will result in erroneous estimates of MGU.

AB - In this study we demonstrated that significant egress of FDG from myocardium occurs within the first hour after tracer injection leading to nonlinear Patlak plots. There are also significant amounts of acidic FDG metabolites present in the blood. However, the impact of these metabolites on the estimates of myocardial glucose utilization (MGU) is negligible. Although further studies will be required to elucidate the reason for the egress of tracer from myocardium, not accounting for it will result in erroneous estimates of MGU.

KW - FDG

KW - Metabolism

KW - Myocardium

KW - Tomography

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SN - 0969-8051

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SP - 883

EP - 892

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JF - Nuclear Medicine and Biology

IS - 7

ER -

Impact of reversible trapping of tracer and the presence of blood metabolites on measurements of myocardial glucose utilization performed by PET and ¹⁸F-fluorodeoxyglucose using the Patlak method

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Keywords

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