TY - JOUR
T1 - Impact of pulmonary vascular resistances in heart transplantation for congenital heart disease
AU - Gazit, Avihu Z.
AU - Canter, Charles E.
N1 - Copyright:
Copyright 2013 Elsevier B.V., All rights reserved.
PY - 2011/5
Y1 - 2011/5
N2 - Congenital heart disease is one of the major diagnoses in pediatric heart transplantation recipients of all age groups. Assessment of pulmonary vascular resistance in these patients prior to transplantation is crucial to determine their candidacy, however, it is frequently inaccurate because of their abnormal anatomy and physiology. This problem places them at significant risk for pulmonary hypertension and right ventricular failure post transplantation. The pathophysiology of pulmonary vascular disease in children with congenital heart disease depends on their pulmonary blood flow patterns, systemic ventricle function, as well as semilunar valves and atrioventricular valves structure and function. In our review we analyze the pathophysiology of pulmonary vascular disease in children with congenital heart disease and end-stage heart failure, and outline the state of the art pre-transplantation medical and surgical management to achieve reverse remodeling of the pulmonary vasculature by using pulmonary vasodilators and mechanical circulatory support.
AB - Congenital heart disease is one of the major diagnoses in pediatric heart transplantation recipients of all age groups. Assessment of pulmonary vascular resistance in these patients prior to transplantation is crucial to determine their candidacy, however, it is frequently inaccurate because of their abnormal anatomy and physiology. This problem places them at significant risk for pulmonary hypertension and right ventricular failure post transplantation. The pathophysiology of pulmonary vascular disease in children with congenital heart disease depends on their pulmonary blood flow patterns, systemic ventricle function, as well as semilunar valves and atrioventricular valves structure and function. In our review we analyze the pathophysiology of pulmonary vascular disease in children with congenital heart disease and end-stage heart failure, and outline the state of the art pre-transplantation medical and surgical management to achieve reverse remodeling of the pulmonary vasculature by using pulmonary vasodilators and mechanical circulatory support.
KW - Congenital heart disease
KW - Heart transplantation
KW - Pulmonary vascular resistance
UR - http://www.scopus.com/inward/record.url?scp=80054727906&partnerID=8YFLogxK
U2 - 10.2174/157340311797484213
DO - 10.2174/157340311797484213
M3 - Review article
C2 - 22548028
AN - SCOPUS:80054727906
SN - 1573-403X
VL - 7
SP - 59
EP - 66
JO - Current Cardiology Reviews
JF - Current Cardiology Reviews
IS - 2
ER -