@article{d3fe69b11aa44be88fefb287a323d0d9,
title = "Impact of prior seasonal influenza vaccination and infection on pandemic A (H1N1) influenza virus replication in ferrets",
abstract = "Early epidemiologic and serologic studies have suggested pre-existing immunity to the pandemic A (H1N1) 2009 influenza virus (H1N1pdm) may be altering its morbidity and mortality in humans. To determine the role that contemporary seasonal H1N1 virus infection or trivalent inactivated vaccine (TIV) might be playing in this immunity we conducted a vaccination-challenge study in ferrets. Vaccination with TIV was unable to alter subsequent morbidity or contact transmission in ferrets following challenge with H1N1pdm. Conversely, prior infection with the contemporary seasonal H1N1 strain altered morbidity, but not transmission, of H1N1pdm despite the detection of only minimal levels of cross reactive antibodies.",
keywords = "Influenza, Pandemic, Vaccine",
author = "Ellebedy, \{A. H.\} and Ducatez, \{M. F.\} and S. Duan and E. Stigger-Rosser and Rubrum, \{A. M.\} and Govorkova, \{E. A.\} and Webster, \{R. G.\} and Webby, \{R. J.\}",
note = "Funding Information: We gratefully acknowledge Heather Forrest, Patrick Seiler, Sharon Lokey, David Carey, Angela Ferguson, and Scott Krauss for their excellent technical assistance, Vani Shanker for editorial assistance. We thank the WHO Global Influenza Surveillance Network for providing the H1N1 viruses and the US National Institute of Allergy and Infectious Diseases (NIAID) for provision of TIV. This study was partially supported by the NIAID (contract no. HHSN266200700005C ), the American Lebanese Syrian Associated Charities . ",
year = "2011",
month = apr,
day = "12",
doi = "10.1016/j.vaccine.2010.08.067",
language = "English",
volume = "29",
pages = "3335--3339",
journal = "Vaccine",
issn = "0264-410X",
number = "17",
}