Impact of preoperative moderate/severe mitral regurgitation on 2-year outcome after transcatheter and surgical aortic valve replacement insight from the placement of aortic transcatheter valve (PARTNER) trial cohort a

Marco Barbanti, John G. Webb, Rebecca T. Hahn, Ted Feldman, Robert H. Boone, Craig R. Smith, Susheel Kodali, Alan Zajarias, Christopher R. Thompson, Philip Green, Vasilis Babaliaros, Raj R. Makkar, Wilson Y. Szeto, Pamela S. Douglas, Tom McAndrew, Irene Hueter, D. Craig Miller, Martin B. Leon

Research output: Contribution to journalArticlepeer-review

115 Scopus citations

Abstract

Background-The effect of preoperative mitral regurgitation (MR) on clinical outcomes of patients undergoing transcatheter aortic valve replacement (TAVR) is controversial. This study sought to examine the impact of moderate and severe MR on outcomes after TAVR and surgical aortic valve replacement (SAVR). Methods and Results-Data were drawn from the randomized Placement of Aortic Transcatheter Valve (PARTNER) Trial cohort A patients with severe, symptomatic aortic stenosis undergoing either TAVR (n=331) or SAVR (n=299). Both TAVR and SAVR patients were dichotomized according to the degree of preoperative MR (moderate/severe versus none/mild). At baseline, moderate or severe MR was reported in 65 TAVR patients (19.6%) and 63 SAVR patients (21.2%). At 30 days, among survivors who had isolated SAVR/TAVR, moderate/severe MR had improved in 25 SAVR patients (69.4%) and 30 TAVR patients (57.7%), was unchanged in 10 SAVR patients (27.8%) and 19 TAVR patients (36.5%), and worsened in 1 SAVR patient (2.8%) and 4 TAVR patients (5.8%; all P=NS). Mortality at 2 years was higher in SAVR patients with moderate or severe MR than in those with mild or less MR (49.8% versus 28.1%; adjusted hazard ratio, 1.73; 95% confidence interval, 1.01-2.96; P=0.04). In contrast, MR severity at baseline did not affect mortality in TAVR patients (37.0% versus 32.7%, moderate/severe versus none/mild; hazard ratio, 1.14; 95% confidence interval, 0.72-1.78; P=0.58; P for interaction=0.05). Conclusions-Both TAVR and SAVR were associated with a significant early improvement in MR in survivors. However, moderate or severe MR at baseline was associated with increased 2-year mortality after SAVR but not after TAVR. TAVR may be a reasonable option in selected patients with combined aortic and mitral valve disease.

Original languageEnglish
Pages (from-to)2776-2784
Number of pages9
JournalCirculation
Volume128
Issue number25
DOIs
StatePublished - Dec 24 2013

Keywords

  • Aortic valve
  • Aortic valve stenosis
  • Heart valve prosthesis implantation
  • Mitral valve insufficiency

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