TY - JOUR
T1 - Impact of perioperative blood transfusion on survival in pancreatic neuroendocrine tumor patients
T2 - analysis from the US Neuroendocrine Study Group
AU - Marincola Smith, Paula
AU - Baechle, Jordan
AU - Solórzano, Carmen C.
AU - Tan, Marcus
AU - Lopez-Aguiar, Alexandra G.
AU - Dillhoff, Mary
AU - Beal, Eliza
AU - Poultsides, George
AU - Cannon, John G.D.
AU - Rocha, Flavio G.
AU - Crown, Angelena
AU - Cho, Clifford
AU - Beems, Megan
AU - Winslow, Emily R.
AU - Rendell, Victoria R.
AU - Krasnick, Bradley A.
AU - Fields, Ryan C.
AU - Maithel, Shishir K.
AU - Bailey, Christina E.
AU - Idrees, Kamran
N1 - Funding Information:
This work was funded in part by the Katz Foundation, National Cancer Institute (Award# F32 CA236309), and the National Center for Advancing Translational Sciences (Award# UL1TR000454 and TL1TR000456). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
Funding Information:
This work was funded in part by the Katz Foundation , National Cancer Institute (Award# F32 CA236309 ), and the National Center for Advancing Translational Sciences (Award# UL1TR000454 and TL1TR000456 ). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. Appendix A
Publisher Copyright:
© 2019 International Hepato-Pancreato-Biliary Association Inc.
PY - 2020/7
Y1 - 2020/7
N2 - Background: Packed red blood cell (PRBC) transfusion has been associated with worse survival in multiple malignancies but its impact on pancreatic neuroendocrine tumors (PNETs) is unknown. The aim of this study was to determine the impact of PRBC transfusion on survival following PNET resection. Methods: A retrospective cohort study of PNET patients was performed using the US Neuroendocrine Tumor Study Group database. Demographic and clinical factors were compared. Kaplan–Meier and log-rank analyses were performed. Factors associated with transfusion, overall (OS), recurrence-free (RFS) and progression-free survival (PFS) were assessed by logistic regression. Results: Of 1129 patients with surgically resected PNETs, 156 (13.8%) received perioperative PRBC transfusion. Transfused patients had higher ASA Class, lower preoperative hemoglobin, larger tumors, more nodal involvement, and increased major complications (all p < 0.010). Transfused patients had worse median OS (116 vs 150 months, p < 0.001), worse RFS (83 vs 128 months, p < 0.01) in curatively resected (n = 1047), and worse PFS (11 vs 24 months, p = 0.110) in non-curatively resected (n = 82) patients. On multivariable analysis, transfusion was associated with worse OS (HR 1.80, p = 0.011) when controlling for TNM stage, tumor grade, final resection status, and pre-operative anemia. Conclusion: PRBC transfusion is associated with worse survival for patients undergoing PNET resection.
AB - Background: Packed red blood cell (PRBC) transfusion has been associated with worse survival in multiple malignancies but its impact on pancreatic neuroendocrine tumors (PNETs) is unknown. The aim of this study was to determine the impact of PRBC transfusion on survival following PNET resection. Methods: A retrospective cohort study of PNET patients was performed using the US Neuroendocrine Tumor Study Group database. Demographic and clinical factors were compared. Kaplan–Meier and log-rank analyses were performed. Factors associated with transfusion, overall (OS), recurrence-free (RFS) and progression-free survival (PFS) were assessed by logistic regression. Results: Of 1129 patients with surgically resected PNETs, 156 (13.8%) received perioperative PRBC transfusion. Transfused patients had higher ASA Class, lower preoperative hemoglobin, larger tumors, more nodal involvement, and increased major complications (all p < 0.010). Transfused patients had worse median OS (116 vs 150 months, p < 0.001), worse RFS (83 vs 128 months, p < 0.01) in curatively resected (n = 1047), and worse PFS (11 vs 24 months, p = 0.110) in non-curatively resected (n = 82) patients. On multivariable analysis, transfusion was associated with worse OS (HR 1.80, p = 0.011) when controlling for TNM stage, tumor grade, final resection status, and pre-operative anemia. Conclusion: PRBC transfusion is associated with worse survival for patients undergoing PNET resection.
UR - http://www.scopus.com/inward/record.url?scp=85076211706&partnerID=8YFLogxK
U2 - 10.1016/j.hpb.2019.10.2441
DO - 10.1016/j.hpb.2019.10.2441
M3 - Article
C2 - 31806388
AN - SCOPUS:85076211706
SN - 1365-182X
VL - 22
SP - 1042
EP - 1050
JO - HPB
JF - HPB
IS - 7
ER -