Impact of pericardial restraint on right atrial mechanics during acute right ventricular pressure load

Hersh S. Maniar, Sunil M. Prasad, Sydney L. Gaynor, Celeste M. Chu, Paul Steendijk, Marc R. Moon

Research output: Contribution to journalArticlepeer-review

34 Scopus citations

Abstract

Optimization of right atrial (RA) mechanics is important for maintaining right ventricular (RV) filling and global cardiac output. However, the impact of pericardial restraint on RA function and the compensatory role of the right atrium to changes in RV afterload remain poorly characterized. In eight open-chest sheep, RA elastance (contractility) and chamber stiffness were measured (RA pressure-volume relations) at baseline and during partial pulmonary artery (PA) occlusion. Data were collected before and after pericardiotomy. With the pericardium intact and partial PA occlusion, RA elastance increased by 28% (P < 0.04), whereas RA stiffness tended to rise (P = 0.08). However, after pericardiotomy, there was a significant fall in both RA elastance (54%, P < 0.04) and stiffness (39%, P < 0.04), and subsequent PA occlusion failed to induce a change in elastance (P > 0.19) or stiffness (P > 0.84). After pericardiotomy, RA elastance and stiffness fell dramatically, and the compensatory response of the right atrium to elevated RV afterload was lost. The ability of the right atrium to respond to changes in RV hemodynamics is highly dependent on pericardial integrity.

Original languageEnglish
Pages (from-to)H350-H357
JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
Volume284
Issue number1 53-1
DOIs
StatePublished - Jan 1 2003

Keywords

  • Atrial function
  • Conductance catheter
  • Pulmonary artery occlusion

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