TY - JOUR
T1 - Impact of OXTR Polymorphisms on Subjective Well-Being
T2 - The Intermediary Role of Attributional Style
AU - Ji, Lei
AU - Chen, Changfeng
AU - Hou, Binyin
AU - Ren, Decheng
AU - Yuan, Fan
AU - Liu, Liangjie
AU - Bi, Yan
AU - Guo, Zhenming
AU - Yang, Fengping
AU - Wu, Xi
AU - Chen, Fujun
AU - Li, Xingwang
AU - Liu, Chuanxin
AU - Zuo, Zhen
AU - Zhang, Rong
AU - Yi, Zhenghui
AU - Xu, Yifeng
AU - He, Lin
AU - Shi, Yi
AU - Yu, Tao
AU - He, Guang
N1 - Publisher Copyright:
Copyright © 2022 Ji, Chen, Hou, Ren, Yuan, Liu, Bi, Guo, Yang, Wu, Chen, Li, Liu, Zuo, Zhang, Yi, Xu, He, Shi, Yu and He.
PY - 2022/2/9
Y1 - 2022/2/9
N2 - Polymorphisms in the oxytocin receptor (OXTR) gene are related to individual differences in negative emotions, such as depressive symptoms and anxiety. However, it remains unclear what the potential roles of OXTR polymorphisms are in subjective well-being (SWB), which is negatively correlated with depressive symptoms. We examined attributional styles as mediator between SWB and five polymorphisms of the oxytocin receptor gene (OXTR rs53576, rs2254298, rs1042778, rs2268494, and rs2268490) among 627 full-time college freshmen (Mage = 20.90, SD = 0.82 for male; Mage = 20.81, SD = 0.92 for female) using structural equation modeling. The results showed that individuals with the OXTR rs2254298 AA genotype and rs53576 AA/GA genotype reported higher scores on SWB, which suggested that individuals with this genotype experienced more happiness. Moreover, external attributional style partially mediated the association between OXTR rs2254298 polymorphism and SWB (β = 0.019, 95%CI [0.001, 0.036], p = 0.035). In conclusion, our findings demonstrated that the genetic variations of OXTR played a role in the individual differences of SWB, and external attribution style could mediate the association.
AB - Polymorphisms in the oxytocin receptor (OXTR) gene are related to individual differences in negative emotions, such as depressive symptoms and anxiety. However, it remains unclear what the potential roles of OXTR polymorphisms are in subjective well-being (SWB), which is negatively correlated with depressive symptoms. We examined attributional styles as mediator between SWB and five polymorphisms of the oxytocin receptor gene (OXTR rs53576, rs2254298, rs1042778, rs2268494, and rs2268490) among 627 full-time college freshmen (Mage = 20.90, SD = 0.82 for male; Mage = 20.81, SD = 0.92 for female) using structural equation modeling. The results showed that individuals with the OXTR rs2254298 AA genotype and rs53576 AA/GA genotype reported higher scores on SWB, which suggested that individuals with this genotype experienced more happiness. Moreover, external attributional style partially mediated the association between OXTR rs2254298 polymorphism and SWB (β = 0.019, 95%CI [0.001, 0.036], p = 0.035). In conclusion, our findings demonstrated that the genetic variations of OXTR played a role in the individual differences of SWB, and external attribution style could mediate the association.
KW - attributional style
KW - intermediary role
KW - OXTR gene polymorphisms
KW - rs2254298 SNP
KW - subjective well-being
UR - https://www.scopus.com/pages/publications/85125133281
U2 - 10.3389/fgene.2021.763628
DO - 10.3389/fgene.2021.763628
M3 - Article
AN - SCOPUS:85125133281
SN - 1664-8021
VL - 12
JO - Frontiers in Genetics
JF - Frontiers in Genetics
M1 - 763628
ER -